pH-controlled Drug Release from Mesoporous Silica Spheres with Switchable Gates

被引：2

作者：

Gao, Qiang ^{[1
,2
]}

Chen, Zongwei ^{[1
,2
]}

Xu, Jun ^{[1
,2
]}

Xu, Yao ^{[3
]}

机构：

[1] China Univ Geosci, Fac Mat Sci & Chem Engn, Wuhan 430074, Peoples R China

[2] China Univ Geosci, Minist Educ, Engn Res Ctr Nano Geomat, Wuhan 430074, Peoples R China

[3] Chinese Acad Sci, Inst Coal Chem, State Key Lab Coal Convers, Taichung 030001, Taiwan

来源：

APPLICATION OF CHEMICAL ENGINEERING, PTS 1-3 | 2011年 / 236-238卷

关键词：

Mesoporous material; Switchable gates; pH-sensitive; Drug release; GUEST MOLECULES;

D O I：

10.4028/www.scientific.net/AMR.236-238.2142

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

Mesoporous silica sphere (MSS) with switchable gates was prepared by the graft of pH-sensitive propyldiethylenetriamine groups (multiamine chains) around mesopore outlets. The textural parameters of the resultant material had been analyzed. In the following test of in vitro drug release, the gated mesoporous material showed high response to solution pH. At high pH (pH 7.5), ibuprofen (IBU) that loaded in this carrier released rapidly and completely (within 2 h); at low pH (pH 4.0 or 5.0), only a small part of the IBU (13 wt%) was slowly released from this carrier and the most of IBU was effectively confined in mesopores.

引用

页码：2142 / +

页数：2

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