Tailoring pH-responsive acrylic acid microgels with hydrophobic crosslinks for drug release

被引：19

作者：

Lu, B. ^{[1
]}

Tarn, M. D. ^{[1
]}

Pamme, N. ^{[1
]}

Georgiou, T. K. ^{[2
]}

机构：

[1] Univ Hull, Dept Chem, Kingston Upon Hull HU6 7RX, N Humberside, England

[2] Univ London Imperial Coll Sci Technol & Med, Dept Mat, London SW7 2AZ, England

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2015年 / 3卷 / 22期

关键词：

AMPHIPHILIC MODEL CONETWORKS; MODIFIED POLY(ACRYLIC ACID); ORGANIC-DYE REMOVAL; METHACRYLIC-ACID; DELIVERY; POLYMER; ARCHITECTURE; HYDROGELS; BEHAVIOR; MICROPARTICLES;

D O I：

10.1039/c5tb00222b

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Amphiphilic microgels based on the hydrophilic acrylic acid (AA) and hydrophobic crosslinks of different compositions were synthesised using a lab-on-a-chip device. The microgels were formed by polymerising hydrophobic droplets. The droplets were generated via a microfluidic platform and contained a protected form of AA, a hydrophobic crosslinker (ethylene glycol dimethacrylate, EGDMA) and a free radical initiator in an organic solvent. Following photopolymerisation and subsequent hydrolysis, AA based microgels of amphiphilic nature were produced and it was demonstrated that they can successfully deliver both hydrophilic as well as hydrophobic moieties. The model drug delivery and the swelling ability of the microgels were influenced by the pH of the aqueous solution as well as the crosslinking density and hydrophobic content of the microgels.

引用

页码：4524 / 4529

页数：6

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