An improvement of FDR for edge detection by applying EM method

被引:0
作者
Kim, Eun-Gyoung [1 ]
Kim, Sung-Ho [1 ]
机构
[1] Korea Adv Inst Sci & Technol, Dept Math Sci, Daejeon, South Korea
基金
新加坡国家研究基金会;
关键词
Discrepancy measure; edge detection; EM algorithm; error rate; graphical Gaussian model; mixture distribution; Parzen window; EMPIRICAL BAYES; CORRELATION-COEFFICIENT; MICROARRAY; LIKELIHOOD; INFERENCE; MODELS;
D O I
10.3233/IDA-216233
中图分类号
TP18 [人工智能理论];
学科分类号
081104 ; 0812 ; 0835 ; 1405 ;
摘要
In building a graphical model, accuracy in edge detection for the model structure is crucial for the quality of the model. We explored methods for improvement of false discovery rate(FDR) by devising an estimation procedure which is more data sensitive under some condition. The estimation is made by applying an EM method where the parameters include the density function under the null hypothesis (no edge) and the location parameters of the density functions under the alternative hypothesis (presence of edge). Our method is compared favorably with a most popular FDR tool in numerical experiments. We applied our method for analysing gene data of 800 genes and built a network of vector autoregressive model for the data.
引用
收藏
页码:1161 / 1184
页数:24
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