Penetration of meropenem in lung, bronchial mucosa, and pleural tissues

被引：22
作者：
Byl, B
Jacobs, F
Roucloux, I
de Franquen, P
Cappello, M
Thys, JP
机构：
[1] Free Univ Brussels, Hop Erasme, Infect Dis Clin, B-1070 Brussels, Belgium
[2] Free Univ Brussels, Hop Erasme, Dept Thorac Surg, B-1070 Brussels, Belgium
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 03期
关键词：
D O I：
10.1128/AAC.43.3.681
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Lung, bronchial mucosa, and pleural tissue samples were obtained from 14 patients undergoing lung surgery 1 to 5 h after administration of 1 g of meropenem. The mean (range) peak concentrations of meropenem were 3.9 (0.2 to 8.2), 6.6 (3.0 to 13.3), and 2.8 (0.6 to 7.8) mg/kg of tissue, respectively, exceeding the MICs at which 90% of isolates are inhibited for most respiratory pathogens.
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页码：681 / 682
页数：2
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