Could fever and neuroinflammation play a role in the neurobiology of autism? A subject worthy of more research

被引：14

作者：

Ghanizadeh, Ahmad ^{[1
]}

机构：

[1] Shiraz Univ Med Sci, Res Ctr Psychiat & Behav Sci, Dept Psychiat, Hafez Hosp, Shiraz, Iran

来源：

INTERNATIONAL JOURNAL OF HYPERTHERMIA | 2011年 / 27卷 / 07期

关键词：

Clinical; hyperthermia; neurotransmitter; treatment; SPECTRUM DISORDERS; CENTRAL MECHANISM; GLUTAMATE; HYPERTHERMIA; CHILDREN; RELEASE;

D O I：

10.3109/02656736.2011.604665

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Autism is neuropsychiatric disorder in which a hyperglutamate state may play a role. It is suggested here that fever or hyperthermia may be able to alter glutamate levels in the brain and may therefore be able to impact on the symptoms of autism. More study on this possibility is clearly warranted.

引用

页码：737 / 738

页数：2

共 20 条

[1] CHANGES IN THE EXTRACELLULAR GLUTAMATE CONCENTRATIONS IN THE RAT CORTEX FOLLOWING LOCALIZED HYPERTHERMIA [J].

ADACHI, H ;

FUJISAWA, H ;

MAEKAWA, T ;

YAMASHITA, T ;

ITO, H .

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 1995, 11 (04) :587-599

[2] Immune-Glutamatergic Dysfunction as a Central Mechanism of the Autism Spectrum Disorders [J].

Blaylock, R. L. ;

Strunecka, A. .

CURRENT MEDICINAL CHEMISTRY, 2009, 16 (02) :157-170

[3]

Blaylock RL, 2009, ALTERN THER HEALTH M, V15, P60

[4]

Chauhan Abha, 2006, Pathophysiology, V13, P171, DOI 10.1016/j.pathophys.2006.05.007

[5] Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: An observation of initial clinical response and maintenance tolerability [J].

Chez, Michael G. ;

Burton, Quinn ;

Dowling, Timothy ;

Chang, Mina ;

Khanna, Pavan ;

Kramer, Christopher .

JOURNAL OF CHILD NEUROLOGY, 2007, 22 (05) :574-579

[6] The hyperglutamatergic hypothesis of autism [J].

Fatemi, S. H. .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2008, 32 (03) :911-911

[7] Does Fever Relieve Autistic Behavior by Improving Brain Blood Flow? [J].

Good, Peter .

NEUROPSYCHOLOGY REVIEW, 2011, 21 (01) :66-67

[8] Blood-mediated scavenging of cerebrospinal fluid glutamate [J].

Gottlieb, M ;

Wang, Y ;

Teichberg, VI .

JOURNAL OF NEUROCHEMISTRY, 2003, 87 (01) :119-126

[9] ELEVATED CSF GLUTAMATE IN RETT SYNDROME [J].

HAMBERGER, A ;

GILLBERG, C ;

PALM, A ;

HAGBERG, B .

NEUROPEDIATRICS, 1992, 23 (04) :212-213

[10] Can Children with Autism Recover? If So, How? [J].

Helt, Molly ;

Kelley, Elizabeth ;

Kinsbourne, Marcel ;

Pandey, Juhi ;

Boorstein, Hilary ;

Herbert, Martha ;

Fein, Deborah .

NEUROPSYCHOLOGY REVIEW, 2008, 18 (04) :339-366

← 1 2 →