Neuropathology of progressive supranuclear palsy

被引:4
作者
Inoue, M
Yagishita, S
Amano, N
Takahashi, T
Hanihara, T
机构
[1] KANAGAWA REHABIL CTR,DIV PATHOL,KANAGAWA,JAPAN
[2] UNIV TOKYO,FAC MED,DEPT NEUROPSYCHIAT,TOKYO 113,JAPAN
[3] YOKOHAMA CITY UNIV,SCH MED,DEPT NEUROL,YOKOHAMA,KANAGAWA 232,JAPAN
[4] YOKOHAMA COMPREHENS CARE CONTINUUM,DEPT PSYCHIAT,YOKOHAMA,KANAGAWA,JAPAN
关键词
glial argyrophilic tangles; neuropathology; progressive supranuclear palsy;
D O I
10.1111/j.1440-1789.1996.tb00191.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The fundamental neuropathological findings of progressive supranuclear palsy (PSP) are presented, based on 14 autopsied cases of PSP, The blunt pathologies of PSP are degeneration in the substantia nigra, globus pallidus, subthalamic nuclei, dentate nucleus of the cerebellum and red nucleus, where there are neuronal loss, gliosis and neurofibrillary changes, to varying degree. In addition, the atrophy of the midbrain, especially the characteristic pattern of tegmental atrophy of the pens exhibiting a hand-bag profile, is an important finding, Hypertrophy of inferior olivary nucleus is frequently observed, suggesting the existence of lesions in the dentato-olivary system, Hypoxemic affects at the agonal stage should be noted because death of Purkinje cells of the cerebellum leads to degeneration of their axons and subsequently to the decrease of grumose degeneration in the dentate nucleus, Familial PSP have been reported by several authors but all cases in the present study were sporadic.
引用
收藏
页码:257 / 261
页数:5
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