Leptin, adiponectin and other adipokines in gestational diabetes mellitus and pre-eclampsia

被引：186
作者：
Miehle, Konstanze [1 ]
Stepan, Holger [2 ]
Fasshauer, Mathias [1 ,3 ]
机构：
[1] Univ Leipzig, Dept Internal Med Endocrinol & Nephrol, Leipzig, Germany
[2] Univ Leipzig, Dept Obstet, Leipzig, Germany
[3] Univ Leipzig, Med Ctr, IFB Adipos Dis, Leipzig, Germany
来源：
CLINICAL ENDOCRINOLOGY | 2012年 / 76卷 / 01期
关键词：
MOLECULAR-WEIGHT ADIPONECTIN; MATERNAL PLASMA LEPTIN; BINDING-PROTEIN; 4; COLONY-ENHANCING FACTOR; NECROSIS-FACTOR-ALPHA; LATE-ONSET PREECLAMPSIA; HUMAN FETAL MEMBRANES; BODY-MASS INDEX; INSULIN-RESISTANCE; NORMAL-PREGNANCY;
D O I：
10.1111/j.1365-2265.2011.04234.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Proteins secreted from adipocytes so-called adipokines influence metabolic and vascular function. Recent data suggest that various adipokines are dysregulated in gestational diabetes mellitus (GDM) and pre-eclampsia (PE) and might be of pathophysiological and prognostic significance in these complications of pregnancy. This review gives an overview on the regulation and pathophysiology of leptin and adiponectin in GDM and PE. Furthermore, data on novel adipokines including resistin, visfatin, retinol-binding protein 4 and vaspin are summarized.
引用
收藏
页码：2 / 11
页数：10
相关论文
共 117 条
  • [1] Increased visfatin and leptin in pregnancies complicated by pre-eclampsia
    Adali, Ertan
    Yildizhan, Recep
    Kolusari, Ali
    Kurdoglu, Mertihan
    Bugdayci, Guler
    Sahin, Hanim Guler
    Kamaci, Mansur
    [J]. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, 2009, 22 (10) : 873 - 879
  • [2] Leptin
    Ahima, RS
    Flier, JS
    [J]. ANNUAL REVIEW OF PHYSIOLOGY, 2000, 62 : 413 - 437
  • [3] Circulating concentrations of adiponectin and tumor necrosis factor-α in gestational diabetes mellitus
    Altinova, Alev E.
    Toruner, Fusun
    Bozkurt, Nuray
    Bukan, Neslihan
    Karakoc, Ayhan
    Yetkin, Ilhan
    Ayvaz, Goksun
    Cakir, Nuri
    Arslan, Metin
    [J]. GYNECOLOGICAL ENDOCRINOLOGY, 2007, 23 (03) : 161 - 165
  • [4] Longitudinal analysis of maternal plasma leptin concentrations during normal pregnancy and pre-eclampsia
    Anim-Nyame, N
    Sooranna, SR
    Steer, PJ
    Johnson, MR
    [J]. HUMAN REPRODUCTION, 2000, 15 (09) : 2033 - 2036
  • [5] Modulation of adipokines and cytokines in gestational diabetes and macrosomia
    Ategbo, J. -M.
    Grissa, O.
    Yessoufou, A.
    Hichami, A.
    Dramane, K. L.
    Moutairou, K.
    Miled, A.
    Grissa, A.
    Jerbi, M.
    Tabka, Z.
    Khan, N. A.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (10) : 4137 - 4143
  • [6] Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes
    Barbour, Linda A.
    McCurdy, Carrie E.
    Hernandez, Teri L.
    Kirwan, John P.
    Catalano, Patrick M.
    Friedman, Jacob E.
    [J]. DIABETES CARE, 2007, 30 : S112 - S119
  • [7] Adipokines and insulin resistance during pregnancy
    Bertha Zavalza-Gomez, Ana
    Anaya-Prado, Roberto
    Rosa Rincon-Sanchez, Ana
    Miguel Mora-Martinez, Jose
    [J]. DIABETES RESEARCH AND CLINICAL PRACTICE, 2008, 80 (01) : 8 - 15
  • [8] Identification of a placental enhancer for the human leptin gene
    Bi, S
    Gavrilova, O
    Gong, DW
    Mason, MM
    Reitman, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (48) : 30583 - 30588
  • [9] Role of visfatin, insulin-like growth factor-I and insulin in fetal growth
    Briana, Despina D.
    Boutsikou, Maria
    Gourgiotis, Dimitrios
    Kontara, Louiza
    Baka, Stavroula
    Iacovidou, Nicoletta
    Hassiakos, Dimitrios
    Malamitsi-Puchner, Ariadne
    [J]. JOURNAL OF PERINATAL MEDICINE, 2007, 35 (04) : 326 - 329
  • [10] What is gestational diabetes?
    Buchanan, Thomas A.
    Xiang, Anny
    Kjos, Sim L.
    Watanabe, Richard
    [J]. DIABETES CARE, 2007, 30 : S105 - S111
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