Synergistic Increase of Serum BDNF in Alzheimer Patients Treated with Cerebrolysin and Donepezil: Association with Cognitive Improvement in ApoE4 Cases

被引：32

作者：

Anton Alvarez, X. ^{[1
]}

Alvarez, Irene ^{[1
,2
]}

Iglesias, Olalla ^{[1
]}

Crespo, Ignacio ^{[1
]}

Figueroa, Jesus ^{[1
,3
]}

Aleixandre, Manuel ^{[4
]}

Linares, Carlos ^{[5
]}

Granizo, Elias ^{[5
]}

Garcia-Fantini, Manuel ^{[6
]}

Marey, Jose ^{[7
]}

Masliah, Eliezer ^{[8
,9
]}

Winter, Stefan ^{[10
]}

Muresanu, Dafin ^{[10
,11
]}

Moessler, Herbert ^{[12
]}

机构：

[1] Clin RehaSalud, Med Inst Neurosci, POB 7010, Y La Coruna 15002, Spain

[2] QPS Holdings, Dept Clin Res, La Coruna, Spain

[3] Hosp Clin Univ, Rehabil Dept, Santiago De Compostela, Spain

[4] Univ Granada, Sch Psychol, Granada, Spain

[5] Complejo Asistencial HHSCJ, Malaga, Spain

[6] Hosp HM Modelo, Dept Neurosurg, La Coruna, Spain

[7] Hosp Clin Univ, Dept Neurol, La Coruna, Spain

[8] Univ Calif San Diego, Sch Med, Dept Neurosci, La Jolla, CA 92093 USA

[9] Univ Calif San Diego, Sch Med, Dept Pathol, La Jolla, CA 92093 USA

[10] Ever NeuroPharma, Unterach, Austria

[11] Univ Med & Pharm Iuliu Hatieganu, Dept Clin Neurosci, Cluj Napoca, Romania

[12] RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania

来源：

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2016年 / 19卷 / 06期

关键词：

Alzheimer's disease; brain derived neurotrophic factor; Cerebrolysin; combination therapy; apolipoprotein E epsilon-4 allele; NEUROTROPHIC FACTOR LEVELS; TRANSGENIC MODEL; DISEASE; EXERCISE; SURVIVAL; GROWTH; CELLS;

D O I：

10.1093/ijnp/pyw024

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Low circulating brain derived neurotrophic factor may promote cognitive deterioration, but the effects of neurotrophic and combination drug therapies on serum brain derived neurotrophic factor were not previously investigated in Alzheimer's disease. Methods: We evaluated the effects of Cerebrolysin, donepezil, and the combined therapy on brain derived neurotrophic factor serum levels at week 16 (end of Cerebrolysin treatment) and week 28 (endpoint) in mild-to-moderate Alzheimer's disease patients. Results: Cerebrolysin, but not donepezil, increased serum brain derived neurotrophic factor at week 16, while the combination therapy enhanced it at both week 16 and study endpoint. Brain derived neurotrophic factor responses were significantly higher in the combination therapy group than in donepezil and Cerebrolysin groups at week 16 and week 28, respectively. Brain derived neurotrophic factor increases were greater in apolipoprotein E epsilon-4 allele carriers, and higher brain derived neurotrophic factor levels were associated with better cognitive improvements in apolipoprotein E epsilon-4 allele patients treated with Cerebrolysin and the combined therapy. Conclusion: Our results indicate a synergistic action of Cerebrolysin and donepezil to increase serum brain derived neurotrophic factor and delaying cognitive decline, particularly in Alzheimer's disease cases with apolipoprotein E epsilon-4 allele.

引用

页码：1 / 6

页数：6

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