Metal-free cascade reactions of aldehydes and primary amines for the synthesis of 1,3,4-trisubstituted pyrroles

被引：8

作者：

Gao, Yong ^{[1
]}

Hu, Changfeng ^{[2
]}

Wan, Jie-Ping ^{[1
]}

Wen, Chengping ^{[2
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Peoples R China

[2] Zhejiang Chinese Med Univ, Coll Basic Med Sci, Hangzhou 310053, Zhejiang, Peoples R China

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 43期

基金：

中国国家自然科学基金;

关键词：

Cascade reaction; Metal-free; Oxidation; Polysubstituted; Pyrroles; HIGHLY SUBSTITUTED PYRROLES; ONE-POT SYNTHESIS; POLYSUBSTITUTED PYRROLES; TETRASUBSTITUTED PYRROLES; MULTICOMPONENT REACTIONS; DIVERGENT SYNTHESIS; HERONAPYRROLE C; CONSTRUCTION; ISOCYANIDES; DERIVATIVES;

D O I：

10.1016/j.tetlet.2016.09.063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 1,3,4-trisubstituted pyrroles has been realized via the cascade reactions of phenylacetaldehydes and primary amines. It is the first time that this annulation involving the construction of one new C-C and two new C-N bonds has been successfully conducted under metal-free conditions. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：4854 / 4857

页数：4

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