Metal-free cascade reactions of aldehydes and primary amines for the synthesis of 1,3,4-trisubstituted pyrroles

被引：8
作者：
Gao, Yong [1 ]
Hu, Changfeng [2 ]
Wan, Jie-Ping [1 ]
Wen, Chengping [2 ]
机构：
[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Peoples R China
[2] Zhejiang Chinese Med Univ, Coll Basic Med Sci, Hangzhou 310053, Zhejiang, Peoples R China
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 43期
基金：
中国国家自然科学基金;
关键词：
Cascade reaction; Metal-free; Oxidation; Polysubstituted; Pyrroles; HIGHLY SUBSTITUTED PYRROLES; ONE-POT SYNTHESIS; POLYSUBSTITUTED PYRROLES; TETRASUBSTITUTED PYRROLES; MULTICOMPONENT REACTIONS; DIVERGENT SYNTHESIS; HERONAPYRROLE C; CONSTRUCTION; ISOCYANIDES; DERIVATIVES;
D O I：
10.1016/j.tetlet.2016.09.063
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of 1,3,4-trisubstituted pyrroles has been realized via the cascade reactions of phenylacetaldehydes and primary amines. It is the first time that this annulation involving the construction of one new C-C and two new C-N bonds has been successfully conducted under metal-free conditions. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4854 / 4857
页数：4
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