Imaging of the dopaminergic neurotransmission system using single-photon emission tomography and positron emission tomography in patients with parkinsonism
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作者:
Booij, J
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机构:Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, Grad Sch Neurosci Amsterdam, NL-1105 AZ Amsterdam, Netherlands
Booij, J
Tissingh, G
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机构:Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, Grad Sch Neurosci Amsterdam, NL-1105 AZ Amsterdam, Netherlands
Tissingh, G
Winogrodzka, A
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机构:Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, Grad Sch Neurosci Amsterdam, NL-1105 AZ Amsterdam, Netherlands
Winogrodzka, A
van Royen, EA
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机构:Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, Grad Sch Neurosci Amsterdam, NL-1105 AZ Amsterdam, Netherlands
van Royen, EA
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[1] Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, Grad Sch Neurosci Amsterdam, NL-1105 AZ Amsterdam, Netherlands
Parkinsonism is a feature of a number of neurodegenerative diseases, including Parkinson's disease, multiple system atrophy and progressive supranuclear palsy. The results of post-mortem studies point to dysfunction of the dopaminergic neurotransmitter system in patients with parkinsonism. Nowadays, by using single-photon emission tomography (SPET) and positron emission tomography (PET) it is possible to visualise both the nigrostriatal dopaminergic neurons and the striatal dopamine D-2 receptors in vivo. Consequently, SPET and PET imaging of elements of the dopaminergic system can play an important role in the diagnosis of several parkinsonian syndromes. This review concentrates on findings of SPET and PET studies of the dopaminergic neurotransmitter system in various parkinsonian syndromes.
机构:
Cedars Sinai Med Ctr, Biomed Imaging Res Inst, Dept Biomed Sci, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Biomed Imaging Res Inst, Dept Biomed Sci, Los Angeles, CA 90048 USA
Dey, Damini
Slomka, Piotr J.
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Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Biomed Imaging Res Inst, Dept Biomed Sci, Los Angeles, CA 90048 USA
Slomka, Piotr J.
Berman, Daniel S.
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机构:
Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA 90048 USA
Cedars Sinai Med Ctr, Cedars Sinai Heart Inst, Los Angeles, CA 90048 USACedars Sinai Med Ctr, Biomed Imaging Res Inst, Dept Biomed Sci, Los Angeles, CA 90048 USA
机构:
Univ Turku, Turku PET Ctr, Kiinamyllynkatu 4-8, FIN-20520 Turku, Finland
Turku Univ Hosp, FIN-20520 Turku, FinlandUniv Turku, Turku PET Ctr, Kiinamyllynkatu 4-8, FIN-20520 Turku, Finland