The oxadiazole antibacterials

被引：39
作者：
Janardhanan, Jeshina [1 ]
Chang, Mayland [1 ]
Mobashery, Shahriar [1 ]
机构：
[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA
来源：
CURRENT OPINION IN MICROBIOLOGY | 2016年 / 33卷
基金：
美国国家卫生研究院;
关键词：
RESISTANT STAPHYLOCOCCUS-AUREUS; PENICILLIN-BINDING PROTEINS; AIDED DRUG DISCOVERY; CELL-WALL; ANTIBIOTICS; METABOLISM; PATHOGENS; ESKAPE; MMPL;
D O I：
10.1016/j.mib.2016.05.009
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The oxadiazoles are a class of antibacterials discovered by in silico docking and scoring of compounds against the X-ray structure of a penicillin-binding protein. These antibacterials exhibit activity against Gram-positive bacteria, including against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). They show in vivo efficacy in murine models of peritonitis/sepsis and neutropenic thigh MRSA infection. They are bactericidal and orally bioavailable. The oxadiazoles show promise in treatment of MRSA infection.
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收藏
页码：13 / 17
页数：5
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