Synthesis of bis-diosgenin pyrazine dimers: New cephalostatin analogs

被引：10
|
作者：
Shawakfeh, Khaled Q. [1 ]
Al-Said, Naim H. [1 ]
Ai-Zoubi, Raed M. [1 ]
机构：
[1] Jordan Univ Sci & Technol, Dept Appl Chem Sci, Irbid 22110, Jordan
来源：
STEROIDS | 2008年 / 73卷 / 06期
关键词：
synthesis; bis-diosgenin pyrazine dimers; cephalostatin analogs;
D O I：
10.1016/j.steroids.2008.01.012
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A convenient synthesis for bis-diosgenin pyrazine dimers, cephalostatin analogues is reported. These symmetrical dimeric steroid-pyrazines were obtained by the classical condensation of a-amino ketones, the most efficient method for pyrazine ring construction. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：579 / 584
页数：6
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