Palladium-Catalyzed Annulation Reactions for Diastereoselective Cyclopentene Synthesis

被引：21
|
作者：
Kohn, Benjamin L. [1 ]
Jarvo, Elizabeth R. [1 ]
机构：
[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 18期
关键词：
ENANTIOSELECTIVE SYNTHESIS; NEUTRAL CONDITIONS; 3+2 CYCLOADDITION; COUPLING REACTION; COMPLEXES; ALLYLATION; PROPARGYL; CASCADE; ALLENES; ALDEHYDES;
D O I：
10.1021/ol2019423
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed annulation reactions of conjugate acceptors and allenyl boronic ester provide substituted cyclopentenes in high yields and, where applicable, diastereoselectivities. This method provides rapid assembly of building blocks for natural product synthesis, including polycyclic lactone and lactam products. Reactions are hypothesized to initiate by conjugate addition of a nucleophilic propargylpalladium complex.
引用
收藏
页码：4858 / 4861
页数：4
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