Oxaliplatin-Induced Lung Injury with Allergic Reaction

被引：4

作者：

Homma, Tetsuya ^{[1
]}

Kurokawa, Masatsugu ^{[1
]}

Yamamoto, Yoshitaka ^{[1
]}

Matsukura, Satoshi ^{[1
]}

Ieki, Koushi ^{[1
]}

Suzuki, Shintaro ^{[1
]}

Odaka, Miho ^{[1
]}

Watanabe, Shin ^{[1
]}

Yamaguchi, Munehiro ^{[1
]}

Adachi, Mitsuru ^{[1
]}

机构：

[1] Showa Univ, Sch Med, Div Allergol & Resp Med, Div Internal Med,Shinagawa Ku, Tokyo 142, Japan

来源：

CHINESE JOURNAL OF CANCER RESEARCH | 2011年 / 23卷 / 03期

关键词：

Oxaliplatin; mFOLFOX6; Drug-induced pneumonia; Drug lymphocyte stimulating test; Immunoglobulin E; OBLITERANS ORGANIZING PNEUMONIA; HYPERSENSITIVITY REACTIONS; COLORECTAL-CANCER; CHEMOTHERAPY; 5-FLUOROURACIL; LEUCOVORIN; DISEASE; FLUOROURACIL; DIAGNOSIS;

D O I：

10.1007/s11670-011-0232-y

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A 79-year-old man was diagnosed as stage IV colon cancer and treated with a modified FOLFOX6 (mFOLFOX6) regimen. On the 12th cycle, we observed erythema and dyspnea. Radiographs showed ground grass opacities. Blood tests showed elevated levels of eosinophils and immunoglobulin E. We diagnosed this finding as response to drug allergy and administered high-dose methylprednisolone. The treatment was successful and he was discharged. The drug lymphocyte stimulating test against oxaliplatin was positive, indicating a type I and IV allergic reaction due to oxaliplatin. Regimens including oxaliplatin must be carefully monitored and frequent blood tests and chest radiographs are needed.

引用

页码：232 / 235

页数：4

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