Human Brain Organoids as an In Vitro Model System of Viral Infectious Diseases

被引：18

作者：

Su, Xuan ^{[1
,2
]}

Yue, Peng ^{[1
,3
]}

Kong, Jing ^{[1
,3
]}

Xu, Xin ^{[1
,4
]}

Zhang, Yu ^{[1
,4
]}

Cao, Wenjing ^{[1
,3
]}

Fan, Yuxin ^{[1
,4
]}

Liu, Meixiao ^{[1
,4
]}

Chen, Jingjing ^{[1
,3
]}

Liu, Aihua ^{[1
,3
]}

Bao, Fukai ^{[1
,4
]}

机构：

[1] Kunming Med Univ, Yunnan Prov Key Lab Trop Infect Dis Univ, Kunming, Yunnan, Peoples R China

[2] Kunming Med Univ, Affiliated Children Hosp, Dept Pediat, Kunming, Yunnan, Peoples R China

[3] Kunming Med Univ, Dept Biochem & Mol Biol, Kunming, Yunnan, Peoples R China

[4] Kunming Med Univ, Dept Microbiol & Immunol, Kunming, Yunnan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2022年 / 12卷

基金：

中国国家自然科学基金;

关键词：

brain organoid; brainoid; infection; virus; prion; model system; pathogenesis; ZIKA VIRUS-INFECTION; CEREBRAL ORGANOIDS; NEURAL PROGENITORS; STEM-CELLS; IMMUNE; DIFFERENTIATION; NEUROGENESIS; DIAGNOSIS; DISRUPTS;

D O I：

10.3389/fimmu.2021.792316

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Brain organoids, or brainoids, have shown great promise in the study of central nervous system (CNS) infection. Modeling Zika virus (ZIKV) infection in brain organoids may help elucidate the relationship between ZIKV infection and microcephaly. Brain organoids have been used to study the pathogenesis of SARS-CoV-2, human immunodeficiency virus (HIV), HSV-1, and other viral infections of the CNS. In this review, we summarize the advances in the development of viral infection models in brain organoids and their potential application for exploring mechanisms of viral infections of the CNS and in new drug development. The existing limitations are further discussed and the prospects for the development and application of brain organs are prospected.

引用

页数：10

共 71 条

[1] Modeling Aβ42 Accumulation in Response to Herpes Simplex Virus 1 Infection: Two Dimensional or Three Dimensional? [J].

Abrahamson, Eric E. ;

Zheng, Wenxiao ;

Muralidaran, Vaishali ;

Ikonomovic, Milos D. ;

Bloom, David C. ;

Nimgaonkar, Vishwajit L. ;

D'Aiuto, Leonardo .

JOURNAL OF VIROLOGY, 2021, 95 (05)

[2] Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres [J].

Abreu, Celina Monteiro ;

Gama, Lucio ;

Krasemann, Susanne ;

Chesnut, Megan ;

Odwin-Dacosta, Shelly ;

Hogberg, Helena T. ;

Hartung, Thomas ;

Pamies, David .

FRONTIERS IN MICROBIOLOGY, 2018, 9

[3] Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells [J].

Ayala-Nunez, Nilda Vanesa ;

Follain, Gautier ;

Delalande, Franois ;

Hirschler, Aurlie ;

Partiot, Emma ;

Hale, Gillian L. ;

Bollweg, Brigid C. ;

Roels, Judith ;

Chazal, Maxime ;

Bakoa, Florian ;

Carocci, Margot ;

Bourdoulous, Sandrine ;

Faklaris, Orestis ;

Zaki, Sherif R. ;

Eckly, Anita ;

Uring-Lambert, Batrice ;

Doussau, Frdric ;

Cianferani, Sarah ;

Carapito, Christine ;

Jacobs, Frank M. J. ;

Jouvenet, Nolwenn ;

Goetz, Jacky G. ;

Gaudin, Raphael .

NATURE COMMUNICATIONS, 2019, 10 (1)

[4] HIV subtype diversity worldwide [J].

Bbosa, Nicholas ;

Kaleebu, Pontiano ;

Ssemwanga, Deogratius .

CURRENT OPINION IN HIV AND AIDS, 2019, 14 (03) :153-160

[5] Cellular mechanisms underlying neurological/neuropsychiatric manifestations of COVID-19 [J].

Bodnar, Brittany ;

Patel, Kena ;

Ho, Wenzhe ;

Luo, Jin Jun ;

Hu, Wenhui .

JOURNAL OF MEDICAL VIROLOGY, 2021, 93 (04) :1983-1998

[6] Herpes Simplex Virus-1 Encephalitis in Adults: Pathophysiology, Diagnosis, and Management [J].

Bradshaw, Michael J. ;

Venkatesan, Arun .

NEUROTHERAPEUTICS, 2016, 13 (03) :493-508

[7] Congenital Human Cytomegalovirus Infection and the Enigma of Maternal Immunity [J].

Britt, William J. .

JOURNAL OF VIROLOGY, 2017, 91 (15)

[8]

Buzhdygan TP, 2020, NEUROBIOL DIS, V146, DOI [10.1101/2020.06.15.150912, 10.1016/j.nbd.2020.105131]

[9] Betulinic Acid Exerts Cytoprotective Activity on Zika Virus-Infected Neural Progenitor Cells [J].

Cavalcante, Bruno R. R. ;

Aragao-Franca, Luciana S. ;

Sampaio, Gabriela L. A. ;

Nonaka, Carolina K. V. ;

Oliveira, Moises S. ;

Campos, Gubio S. ;

Sardi, Silvia I. ;

Dias, Beatriz R. S. ;

Menezes, Juliana P. B. ;

Rocha, Vinicius P. C. ;

Rossi, Erik A. ;

Paredes, Bruno D. ;

Martins, Gabriele L. S. ;

Allahdadi, Kyan J. ;

Peixoto, Laisla R. ;

Barbosa-Filho, Jose M. ;

Souza, Bruno S. F. ;

Soares, Milena B. P. .

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2020, 10

[10] Mammalian cell cultures as models for Mycobacterium tuberculosis-human immunodeficiency virus (HIV) interaction studies: A review [J].

Chingwaru, Walter ;

Glashoff, Richard H. ;

Vidmar, Jerneja ;

Kapewangolo, Petrina ;

Sampson, Samantha L. .

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE, 2016, 9 (09) :809-816

← 1 2 3 4 5 6 7 8 →