The role of asenapine in the treatment of manic or mixed states associated with bipolar I disorder

被引：12

作者：

Pompili, Maurizio ^{[1
,2
]}

Venturini, Paola ^{[1
]}

Innamorati, Marco ^{[1
]}

Serafini, Gianluca ^{[1
]}

Telesforo, Ludovica ^{[1
]}

Lester, David ^{[3
]}

Tatarelli, Roberto ^{[1
]}

Girardi, Paolo ^{[1
]}

机构：

[1] Univ Roma La Sapienza, StAndrea Hosp, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Funct, I-00189 Rome, Italy

[2] Harvard Univ, Sch Med, McLean Hosp, Boston, MA USA

[3] Richard Stockton Coll New Jersey, Pomona, NJ USA

来源：

NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2011年 / 7卷

关键词：

asenapine; bipolar disorder; side effects; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; PRIMARY-CARE; SCHIZOPHRENIA; EFFICACY; CONSEQUENCES; PREVENTION; DEPRESSION; OLANZAPINE; ADHERENCE;

D O I：

10.2147/NDT.S17259

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Bipolar disorders (BD) are of particular public health significance as they are prevalent, severe and disabling, and often associated with elevated risks of premature mortality. The aim of this concise overview is to investigate the role of asenapine in the treatment of manic and mixed states associated with BD type 1 disorder. Method: MedLine, Excerpta Medica and PsycINFO searches were performed to identify papers in English published over the past 7 years. Search terms were "asenapine", "manic" OR "mixed states", "bipolar I disorder". Subjects included in this study suffered from BD type 1 disorder. Results: To date, only four studies of asenapine for the treatment of manic or mixed episodes associated with BD type 1 have been published. Conclusion: Research indicates that asenapine is generally well-tolerated, and that asenapine is efficacious and not inferior to olanzapine in the treatment of mixed or manic episodes associated with BD type 1 in the short-term and long-term.

引用

页码：259 / 265

页数：7

共 24 条

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