Pediatric Ependymoma

被引：31
作者：
Vitanza, Nicholas A. [1 ]
Partap, Sonia [1 ]
机构：
[1] Stanford Univ, Lucile Packard Childrens Hosp Stanford, Dept Neurol, Div Child Neurol, Palo Alto, CA 94304 USA
来源：
JOURNAL OF CHILD NEUROLOGY | 2016年 / 31卷 / 12期
关键词：
childhood brain tumor; central nervous system cancer; CONFORMAL RADIATION-THERAPY; TUMOR-SUPPRESSOR GENE; UNIQUE MOLECULAR CHARACTERISTICS; CHILDHOOD BRAIN-TUMORS; CHILDRENS CANCER GROUP; CENTRAL-NERVOUS-SYSTEM; PROGNOSTIC-FACTORS; INTRACRANIAL EPENDYMOMAS; POSTOPERATIVE CHEMOTHERAPY; RECURRENT EPENDYMOMA;
D O I：
10.1177/0883073815610428
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Over the past 150 years since Virchow's initial characterization of ependymoma, incredible efforts have been made in the classification of these tumors and in the care of pediatric patients with this disease. While the advent of modern neurosurgery and the optimization of radiation have provided significant gains, a more complex but incomplete picture of pediatric ependymomas has begun to form through a combination of international collaborations and detailed genetic and histologic characterizations. This review includes and synthesizes the clinical understanding of pediatric ependymoma and their developing molecular insight into what is truly a family of malignancies in which distinct members require different surgical approaches, radiation plans, and targeted therapies.
引用
收藏
页码：1354 / 1366
页数：13
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