Difference in age of onset of psychosis between epilepsy and schizophrenia

被引:19
作者
Adachi, Naoto [1 ,2 ]
Hara, Tsunekatsu [3 ]
Oana, Yasunori [4 ]
Matsuura, Masato
Okubo, Yoshiro [6 ]
Akanuma, Nozomi [2 ]
Ito, Masumi [2 ]
Kato, Masaaki [2 ,5 ]
Onuma, Tefichi [2 ]
机构
[1] Adachi Mental Clin, Sapporo, Hokkaido 0040867, Japan
[2] Natl Ctr Hosp Mental Nervous & Muscular Disorder, NCNP, Tokyo, Japan
[3] Komagino Hosp, Tokyo, Japan
[4] Tokyo Med Univ Hosp, Dept Neuropsychiat, Tokyo, Japan
[5] Nihon Univ Hosp, Dept Neuropsychiat, Tokyo, Japan
[6] Tokyo Med & Dent Univ Hosp, Dept Neuropsychiat, Tokyo, Japan
关键词
epilepsy; psychosis; schizophrenia; age of onset; sex difference; family history;
D O I
10.1016/j.eplepsyres.2007.12.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
To clarify the nature of psychosis development in epilepsy patients, we studied differences in age of onset of psychosis between epilepsy patients with psychosis (epilepsy-psychosis) and schizophrenia patients. Subjects were 282 patients with epilepsy-psychosis (36 postictal, 224 interictal, and 22 bimodal psychoses) and 612 schizophrenia patients. Age of onset was compared between the schizophrenia group and the whole epilepsy-psychosis group as we[[ as its subgroups. Effects of sex and family history of psychosis on age of onset were also evaluated. Epilepsy patients developed psychosis later (mean age 30.1) than schizophrenia patients (mean age 26.6). Among epilepsy-psychosis subgroups, postictal. psychosis and interictal psychosis showed a later onset than schizophrenia. In interictal psychosis, white chronic schizophrenia-like psychosis occurred at similar age compared to schizophrenia, brief episodic psychosis occurred at Later age. Epilepsy-psychosis patients showed no sex difference in age of onset, whereas female schizophrenia patients showed a later onset than mate schizophrenia patients. Both the epilepsy and schizophrenia patients with family history of psychosis tended to develop psychosis at an earlier age, although this did not reach statistically significant level. The findings of the study suggest that the nature of epilepsy-psychosis is not fully equivalent to that of schizophrenia. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:201 / 206
页数:6
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