Longterm Followup After Tapering Mycophenolate Mofetil During Maintenance Treatment for Proliferative Lupus Nephritis

被引：16

作者：

Laskari, Katerina ^{[1
]}

Tzioufas, Athanasios G. ^{[1
]}

Antoniou, Anna ^{[2
]}

Moutsopoulos, Haralampos M. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Pathophysiol, GR-11527 Athens, Greece

[2] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

来源：

JOURNAL OF RHEUMATOLOGY | 2011年 / 38卷 / 07期

关键词：

LUPUS NEPHRITIS; MAINTENANCE TREATMENT; MYCOPHENOLATE MOFETIL; CLASSIFICATION; ERYTHEMATOSUS; THERAPY;

D O I：

10.3899/jrheum.101249

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To determine the timing for safe reduction of mycophenolate mofetil (MMF) dose during remission-maintenance therapy of proliferative lupus nephritis. Methods. The study population consisted of 44 patients evaluated retrospectively; MMF dose was empirically tapered in 18/44 patients until the latest observation. Results. Patients reducing MMF <= 18 months after remission/complete remission had a 6.8-fold/6.3-fold higher risk of relapse compared to those taking a stable dose (p = 0.001, p = 0.011, respectively). Reducing MMF later than 18 months was not associated with increased relapse rates. Conclusion. Reducing MMF > 1.5 years after remission/complete remission seems to warrant drug tapering without increased risk of disease flare in proliferative lupus nephritis. (J Rheumatol First Release April 15 2011; doi:10.3899/jrheum.101249)

引用

页码：1304 / 1308

页数：5

共 50 条

[31] Mycophenolate mofetil versus azathioprine as maintenance therapy for lupus nephritis: A meta-analysis [J].

Feng, Li ;

Deng, Jin ;

Huo, Dong-Mei ;

Wu, Qiao-Yuan ;

Liao, Yun-Hua .

NEPHROLOGY, 2013, 18 (02) :104-110

[32] Comparative Effectiveness of Mycophenolate Mofetil for the Treatment of Juvenile-Onset Proliferative Lupus Nephritis [J].

Tian, Simon Y. ;

Silverman, Earl D. ;

Pullenayegum, Eleanor ;

Brown, Patrick E. ;

Beyene, Joseph ;

Feldman, Brian M. .

ARTHRITIS CARE & RESEARCH, 2017, 69 (12) :1887-1894

[33] Successful treatment of a mycophenolate mofetil-refractory proliferative lupus nephritis with Belimumab in a 19-year-old woman [J].

Fliesser, E. E. ;

Korsten, P. ;

Koziolek, M. J. ;

Niewold, T. B. ;

Patschan, D. ;

Mueller, G. A. ;

Patschan, S. A. .

LUPUS, 2013, 22 (14) :1523-1525

[34] Interest of mycophenolate mofetil in children with membranous lupus nephritis [J].

Gargah, Tahar ;

Goucha-Louzir, Rim ;

Lakhoua, Mohamed Rachid .

NEPHROLOGIE & THERAPEUTIQUE, 2010, 6 (07) :564-568

[35] Multitarget therapy of mycophenolate mofetil and cyclosporine A for induction treatment of refractory lupus nephritis [J].

Jesus, D. ;

Rodrigues, M. ;

da Silva, J. A. P. ;

Ines, L. .

LUPUS, 2018, 27 (08) :1358-1362

[36] The efficacy of low-dose mycophenolate mofetil for treatment of lupus nephritis in Taiwanese patients with systemic lupus erythematosus [J].

Weng, Meng-Yu ;

Weng, Chia-Tse ;

Liu, Ming-Fei .

CLINICAL RHEUMATOLOGY, 2010, 29 (07) :771-775

[37] Surveillance for the use of mycophenolate mofetil for adult patients with lupus nephritis in Japan [J].

Yasuda, Shinsuke ;

Atsumi, Tatsuya ;

Shimamura, Sanae ;

Ono, Kota ;

Hiromura, Keiju ;

Sada, Kenei ;

Mori, Masaaki ;

Takei, Syuji ;

Kawaguchi, Yasushi ;

Tamura, Naoto ;

Takasaki, Yoshinari .

MODERN RHEUMATOLOGY, 2015, 25 (06) :854-857

[38] Investigation on the benefits of mycophenolate mofetil and therapeutic drug monitoring in the treatment of Japanese patients with lupus nephritis [J].

Katsuno, Takayuki ;

Ozaki, Takenori ;

Ozeki, Takaya ;

Hachiya, Asaka ;

Kim, Hangsoo ;

Kato, Noritoshi ;

Ishimoto, Takuji ;

Kato, Sawako ;

Kosugi, Tomoki ;

Tsuboi, Naotake ;

Mizuno, Masashi ;

Ito, Yasuhiko ;

Maruyama, Shoichi .

CLINICAL AND EXPERIMENTAL NEPHROLOGY, 2018, 22 (06) :1341-1350

[39] The effect of mycophenolate mofetil on primary and secondary treatment of primary glomerulonephritis and lupus nephritis [J].

Paydas, Saime ;

Kurt, Cemal ;

Taskapan, Hulya ;

Balal, Mustafa ;

Sertdemir, Yasar ;

Pembegul, Irem .

INTERNATIONAL UROLOGY AND NEPHROLOGY, 2009, 41 (01) :145-152

[40] Comparison of low-dose intravenous cyclophosphamide with oral mycophenolate mofetil in the treatment of lupus nephritis [J].

Rathi, Manish ;

Goyal, Ajay ;

Jaryal, Ajay ;

Sharma, Aman ;

Gupta, Pramod K. ;

Ramachandran, Raja ;

Kumar, Vivek ;

Kohli, Harbir S. ;

Sakhuja, Vinay ;

Jha, Vivekanand ;

Gupta, Krishan L. .

KIDNEY INTERNATIONAL, 2016, 89 (01) :235-242

← 1 2 3 4 5 →