Longterm Followup After Tapering Mycophenolate Mofetil During Maintenance Treatment for Proliferative Lupus Nephritis

被引：16

作者：

Laskari, Katerina ^{[1
]}

Tzioufas, Athanasios G. ^{[1
]}

Antoniou, Anna ^{[2
]}

Moutsopoulos, Haralampos M. ^{[1
]}

机构：

[1] Univ Athens, Sch Med, Dept Pathophysiol, GR-11527 Athens, Greece

[2] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece

来源：

JOURNAL OF RHEUMATOLOGY | 2011年 / 38卷 / 07期

关键词：

LUPUS NEPHRITIS; MAINTENANCE TREATMENT; MYCOPHENOLATE MOFETIL; CLASSIFICATION; ERYTHEMATOSUS; THERAPY;

D O I：

10.3899/jrheum.101249

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To determine the timing for safe reduction of mycophenolate mofetil (MMF) dose during remission-maintenance therapy of proliferative lupus nephritis. Methods. The study population consisted of 44 patients evaluated retrospectively; MMF dose was empirically tapered in 18/44 patients until the latest observation. Results. Patients reducing MMF <= 18 months after remission/complete remission had a 6.8-fold/6.3-fold higher risk of relapse compared to those taking a stable dose (p = 0.001, p = 0.011, respectively). Reducing MMF later than 18 months was not associated with increased relapse rates. Conclusion. Reducing MMF > 1.5 years after remission/complete remission seems to warrant drug tapering without increased risk of disease flare in proliferative lupus nephritis. (J Rheumatol First Release April 15 2011; doi:10.3899/jrheum.101249)

引用

页码：1304 / 1308

页数：5

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