Adjuvants and Vector Systems for Allergy Vaccines

被引：35

作者：

Moingeon, Philippe ^{[1
]}

Lombardi, Vincent ^{[1
]}

Saint-Lu, Nathalie ^{[1
]}

Tourdot, Sophie ^{[1
]}

Bodo, Veronique ^{[1
]}

Mascarell, Laurent ^{[1
]}

机构：

[1] Stallergenes, Res & Dev, F-92160 Antony, France

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2011年 / 31卷 / 02期

关键词：

Adjuvants; Allergy vaccine; Immunopotentiation; Immunotherapy; Mucosal immunity; Vector system; GRASS-POLLEN IMMUNOTHERAPY; MONOPHOSPHORYL-LIPID-A; REGULATORY T-CELLS; ENHANCES TOLERANCE INDUCTION; KILLED MYCOBACTERIUM-VACCAE; ANTIGEN-SPECIFIC TOLERANCE; ORAL DENDRITIC CELLS; LACTIC-ACID BACTERIA; VIRUS-LIKE PARTICLES; HOUSE-DUST MITES;

D O I：

10.1016/j.iac.2011.03.001

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Allergen-specific immunotherapy represents a curative treatment of type I allergies. Subcutaneous immunotherapy is conducted with allergens adsorbed on aluminum hydroxide or calcium phosphate particles, whereas sublingual immunotherapy relies on high doses of soluble allergen without any immunopotentiator. There is a potential benefit of adjuvants enhancing regulatory and Thl CD4+T cell responses during specific immunotherapy. Molecules affecting dendritic cells favor the induction of T regulatory cell and Thl responses and represent valid candidate adjuvants for allergy vaccines. Furthermore, the interest in viruslike particles and mucoadhesive particulate vector systems, which may better address the allergen(s) to tolerogenic antigen-presenting cells, is documented.

引用

页码：407 / +

页数：14

共 100 条

[71] 1α,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation [J].