The Inter-Relationship of Periostin, TGFβ, and BMP in Heart Valve Development and Valvular Heart Diseases

被引：48
作者：
Conway, Simon J. [2 ]
Doetschman, Thomas [1 ,3 ]
Azhar, Mohamad [1 ,3 ]
机构：
[1] Univ Arizona, Inst BIO5, Tucson, AZ 85721 USA
[2] Indiana Univ Sch Med, Wells Ctr Pediat Res, Riley Heart Res Ctr, Indianapolis, IN USA
[3] Univ Arizona, Dept Cellular & Mol Med, Tucson, AZ USA
来源：
THESCIENTIFICWORLDJOURNAL | 2011年 / 11卷
基金：
美国国家卫生研究院;
关键词：
periostin; transforming growth factor beta; TGF beta; bone morphogenetic protein; BMP; heart development; heart valves; Marfan syndrome; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; BONE MORPHOGENETIC PROTEIN-2; OSTEOBLAST-SPECIFIC FACTOR; EPICARDIUM-DERIVED CELLS; OUTFLOW-TRACT SEPTATION; BICUSPID AORTIC-VALVE; ENDOCARDIAL CUSHION; TRANSFORMING GROWTH-FACTOR-BETA-1; CARDIOVASCULAR DEVELOPMENT;
D O I：
10.1100/tsw.2011.132
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Recent studies have suggested an important role for periostin and transforming growth factor beta (TGF beta) and bone morphogenetic protein (BMP) ligands in heart valve formation and valvular heart diseases. The function of these molecules in cardiovascular development has previously been individually reviewed, but their association has not been thoroughly examined. Here, we summarize the current understanding of the association between periostin and TGF beta and BMP ligands, and discuss the implications of this association in the context of the role of these molecules in heart valve development and valvular homeostasis. Information about hierarchal connections between periostin and TGF beta and BMP ligands in valvulogenesis will increase our understanding of the pathogenesis, progression, and medical treatment of human valve diseases.
引用
收藏
页码：1509 / 1524
页数：16
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