Remembering one's identity: the epigenetic basis of stem cell fate decisions

被引：10
作者：
Sen, George L. [1 ]
机构：
[1] Univ Calif San Diego, Dept Med, Dept Cellular & Mol Med, Div Dermatol,Program Stem Cell Biol, San Diego, CA 92103 USA
来源：
FASEB JOURNAL | 2011年 / 25卷 / 07期
关键词：
DNA methylation; differentiation; histone modification; CPG-BINDING-PROTEIN; DNA METHYLATION; HEMATOPOIETIC STEM; SELF-RENEWAL; DEVELOPMENTAL REGULATORS; DEMETHYLASE JMJD3; MOUSE DEVELOPMENT; GENE-EXPRESSION; POLYCOMB; METHYLTRANSFERASE;
D O I：
10.1096/fj.11-182774
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Stem cells serve a vital role in multicellular organisms by constantly replenishing tissue with their differentiated progeny during normal homeostasis or damage. How these cells maintain their identities throughout the life of an organism is an area of intense research. In this review, we explore recent emerging evidence that stem cell fate decisions are based on their epigenome and specific epigenetic factors.-Sen, G. L. Remembering one's identity: the epigenetic basis of stem cell fate decisions. FASEB J. 25, 2123-2128 (2011). www.fasebj.org
引用
收藏
页码：2123 / 2128
页数：6
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