Nanotechnology for enrichment and detection of circulating tumor cells

被引：9

作者：

Bhana, Saheel ^{[1
]}

Wang, Yongmei ^{[1
]}

Huang, Xiaohua ^{[1
]}

机构：

[1] Univ Memphis, Dept Chem, Memphis, TN 38152 USA

来源：

NANOMEDICINE | 2015年 / 10卷 / 12期

关键词：

circulating tumor cells; detection; enrichment; functional nanoparticles; microfluidics; nanostructured substrates; nanotechnology; METASTATIC BREAST-CANCER; IRON-OXIDE NANOPARTICLES; IN-VIVO; FLOW-CYTOMETRY; EFFICIENT CAPTURE; PERIPHERAL-BLOOD; QUANTUM DOTS; SEMICONDUCTOR NANOCRYSTALS; MOLECULAR CHARACTERIZATION; SENSITIVE DETECTION;

D O I：

10.2217/NNM.15.32

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Circulating tumor cells (CTCs) are a hallmark of invasive behavior of cancer, responsible for the development of metastasis. Their detection and analysis have significant impacts in cancer biology and clinical practice. However, CTCs are rare events and contain heterogeneous subpopulations, requiring highly sensitive and specific techniques to identify and capture CTCs with high efficiency. Nanotechnology shows strong promises for CTC enrichment and detection owning to the unique structural and functional properties of nanoscale materials. In this review, we discuss the CTC enrichment and detection technologies based on a variety of functional nanosystems and nanostructured substrates, with the goal to highlight the role of nanotechnology in the advancement of basic and clinical CTC research.

引用

页码：1973 / 1990

页数：18

共 139 条

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