The Vasculature in Chagas Disease

被引：26

作者：

Prado, Cibele M. ^{[1
]}

Jelicks, Linda A. ^{[4
]}

Weiss, Louis M. ^{[2
,3
]}

Factor, Stephen M. ^{[2
,3
]}

Tanowitz, Herbert B. ^{[2
,3
,5
]}

Rossi, Marcos A. ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Pathol, Lab Cellular & Mol Cardiol, Fac Med Ribeirao Preto, Sao Paulo, Brazil

[2] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10467 USA

[3] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA

[4] Albert Einstein Coll Med, Dept Physiol & Biophys, Bronx, NY 10467 USA

[5] Albert Einstein Coll Med, Diabet Res Ctr, Bronx, NY 10467 USA

来源：

ADVANCES IN PARASITOLOGY, VOL 76: CHAGAS DISEASE, PT B | 2011年 / 76卷

关键词：

TRYPANOSOMA-CRUZI INFECTION; HUMAN-ENDOTHELIAL-CELLS; SMOOTH-MUSCLE-CELLS; HEART-DISEASE; ADHESION MOLECULES; BRAZIL STRAIN; MURINE MODEL; CARDIOMYOPATHY; EXPRESSION; PATHOGENESIS;

D O I：

10.1016/B978-0-12-385895-5.00004-9

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The cardiovascular manifestations of Chagas disease are well known. However, the contribution of the vasculature and specifically the microvasculature has received little attention. This chapter reviews the evidence supporting the notion that alterations in the microvasculature especially in the heart contribute to the pathogenesis of chagasic cardiomyopathy. These data may also be important in understanding the contributions of the microvasculature in the aetiologies of other cardiomyopathies. The role of endothelin-1 and of thromboxane A(2) vascular spasm and platelet aggregation is also discussed. Further, these observations may provide target(s) for intervention.

引用

页码：83 / 99

页数：17

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