Lipoprotein apheresis for the treatment of elevated circulating levels of lipoprotein(a): a critical literature review

被引：17
作者：
Franchini, Massimo [1 ]
Capuzzo, Enrico [1 ]
Liumbruno, Giancarlo M. [2 ]
机构：
[1] Carlo Poma Hosp, Dept Haematol & Transfus Med, Mantua, Italy
[2] Italian Natl Blood Ctr, Natl Inst Hlth, Rome, Italy
来源：
BLOOD TRANSFUSION | 2016年 / 14卷 / 05期
关键词：
lipoprotein apheresis; lipoprotein(a); thrombosis; TRANSFER PROTEIN INHIBITOR; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; FAMILIAL HYPERCHOLESTEROLEMIA; LIPID APHERESIS; DOUBLE-BLIND; RISK-FACTOR; LDL-C; SAFETY; EFFICACY;
D O I：
10.2450/2015.0163-15
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Lipoprotein(a), which consists of a low-density lipoprotein (LDL) particle linked to an apolipoprotein(a) moiety, is currently considered an independent risk factor for cardiovascular disease due to its atherogenic (LDL-like) and prothrombotic (plasminogen-like) properties. The aim of this review is to provide an overview of the current and newer therapies for lowering increased lipoprotein(a) levels, focusing on lipoprotein apheresis. After a systematic literature search, we identified ten studies which, overall, documented that lipoprotein apheresis is effective in reducing increased lipoprotein(a) levels and cardiovascular events.
引用
收藏
页码：413 / 418
页数：6
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