Lipoprotein apheresis for the treatment of elevated circulating levels of lipoprotein(a): a critical literature review

被引：17

作者：

Franchini, Massimo ^{[1
]}

Capuzzo, Enrico ^{[1
]}

Liumbruno, Giancarlo M. ^{[2
]}

机构：

[1] Carlo Poma Hosp, Dept Haematol & Transfus Med, Mantua, Italy

[2] Italian Natl Blood Ctr, Natl Inst Hlth, Rome, Italy

来源：

BLOOD TRANSFUSION | 2016年 / 14卷 / 05期

关键词：

lipoprotein apheresis; lipoprotein(a); thrombosis; TRANSFER PROTEIN INHIBITOR; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; FAMILIAL HYPERCHOLESTEROLEMIA; LIPID APHERESIS; DOUBLE-BLIND; RISK-FACTOR; LDL-C; SAFETY; EFFICACY;

D O I：

10.2450/2015.0163-15

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Lipoprotein(a), which consists of a low-density lipoprotein (LDL) particle linked to an apolipoprotein(a) moiety, is currently considered an independent risk factor for cardiovascular disease due to its atherogenic (LDL-like) and prothrombotic (plasminogen-like) properties. The aim of this review is to provide an overview of the current and newer therapies for lowering increased lipoprotein(a) levels, focusing on lipoprotein apheresis. After a systematic literature search, we identified ten studies which, overall, documented that lipoprotein apheresis is effective in reducing increased lipoprotein(a) levels and cardiovascular events.

引用

页码：413 / 418

页数：6

共 50 条

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