Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature

被引：2
作者：
Basiri, Ali [1 ]
Edelstein, Daniel L.
Graham, Jenna [2 ]
Nabili, Afshin [1 ]
Giardiello, Francis M.
Ramella-Roman, Jessica C. [1 ,2 ]
机构：
[1] Catholic Univ Amer, Washington, DC 20064 USA
[2] Johns Hopkins Univ, Appl Phys Lab, Baltimore, MD 21218 USA
来源：
JOURNAL OF BIOPHOTONICS | 2011年 / 4卷 / 10期
关键词：
colon cancer; oral mucosa; reflectance; vessel density; LIGHT REFLECTANCE; HIGH-RISK; CANCER; COMPLEXITY; MARKER;
D O I：
10.1002/jbio.201100057
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. We investigated a novel spectro-polarimetric imaging system capable of capturing high-resolution images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Results of a clinical trial show that the system is capable of separating FAP positive individuals from controls by measuring the individuals' oral vascular density and complexity. [GRAPHICS] Typical image of the oral mucosa.
引用
收藏
页码：707 / 714
页数：8
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