Human Fatty Liver Disease: Old Questions and New Insights

被引：1722

作者：

Cohen, Jonathan C. ^{[1
]}

Horton, Jay D. ^{[1
,2
]}

Hobbs, Helen H. ^{[1
,2
,3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Mol Genet, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA

来源：

SCIENCE | 2011年 / 332卷 / 6037期

关键词：

INSULIN-RESISTANCE; HEPATIC STEATOSIS; NONALCOHOLIC STEATOHEPATITIS; ADIPOSE-TISSUE; PREVALENCE; GLUCOSE; TRANSPLANTATION; CHOLESTEROL; LIPOGENESIS; POPULATION;

D O I：

10.1126/science.1204265

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-third of adults and an increasing number of children in developed countries. The disease begins with the aberrant accumulation of triglyceride in the liver, which in some individuals elicits an inflammatory response that can progress to cirrhosis and liver cancer. Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood, and therapeutic options are limited. Here, we discuss recent mechanistic insights into NAFLD, focusing primarily on those that have emerged from human genetic and metabolic studies.

引用

页码：1519 / 1523

页数：5

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