The design of antiparallel coiled coils

被引：124
|
作者：
Oakley, MG [1 ]
Hollenbeck, JJ [1 ]
机构：
[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 2001年 / 11卷 / 04期
关键词：
D O I：
10.1016/S0959-440X(00)00232-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent structural studies have highlighted the importance of antiparallel coiled coils in nature. In addition, well-behaved, model antiparallel coiled coils have been designed and used for the reassembly of protein fragments and for the study of the energetic contributions of various interactions to helix orientation specificity. Finally, high-resolution structural data are available for designed helical bundles, allowing an evaluation of the success of state-of-the-art protein design efforts.
引用
收藏
页码：450 / 457
页数：8
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