Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma

被引:57
作者
Breuhahn, Kai [1 ]
Schirmacher, Peter [1 ]
机构
[1] Univ Heidelberg Hosp, Inst Pathol, D-69120 Heidelberg, Germany
关键词
hepatocellular carcinoma; insulin-like growth factor-II; insulin-like growth factor-I receptor; insulin receptor substrate; mouse models; therapy;
D O I
10.3748/wjg.14.1690
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Constitutive activation of the insulin-like growth factor (IGF)-signaling axis is frequently observed in human hepatocellular carcinoma (HCC). Especially the overexpression of the fetal growth factor IGF-II, IGF-I receptor (IGF-IR), and cytoplasmic downstream effectors such as insulin-receptor substrates (IRS) contribute to proliferation, anti-apoptosis, and invasive behavior. This review focuses on the relevant alterations in this signaling pathway and independent in vivo models that support the central role IGF-II signaling during HCC development and progression. Since this pathway has become the center of interest as a target for potential anti-cancer therapy in many types of malignancies, various experimental strategies have been developed, including neutralizing antibodies and selective receptor kinase inhibitors, with respect to the specific and efficient reduction of oncogenic IGF-II/IGF-IR-signaling. (c) 2008 WJG. All rights reserved.
引用
收藏
页码:1690 / 1698
页数:9
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