Preliminary study of letrozole use for improving spermatogenesis in non-obstructive azoospermia patients with normal serum FSH

被引：34

作者：

Cavallini, Giorgio ^{[1
]}

Beretta, Giovanni ^{[2
]}

Biagiotti, Giulio ^{[3
]}

机构：

[1] Andros Italia, Outpatient Clin Ferrara, I-44121 Ferrara, Italy

[2] Ctr Italiano Fertilita & Sessualita, I-50129 Florence, Italy

[3] Andros Italia, Sede Perugia, I-06128 Perugia, Italy

来源：

ASIAN JOURNAL OF ANDROLOGY | 2011年 / 13卷 / 06期

关键词：

letrozole; medical treatment; non-obstructive azoospermia; spermatogenesis; AROMATASE INHIBITORS; WOMEN;

D O I：

10.1038/aja.2011.44

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

We investigated whether letrozole (2.5 mg day(-1)) improves sperm count in non-obstructive azoospermia (NOA) patients. Four men were included in this study, and they had folliculo-stimulating hormone and other hormone levels within the normal range and no varicoceles or chromosomal aberrations. These four patients were administered letrozole for 3 months. Sperm count, testicular volume, gonadotropin, testosterone (T) and estradiol (E2) blood levels were assessed before, during and 1 week after the suspension of treatment. All patients showed spermatozoa in their ejaculate, increased gonadotropin and T levels and lower E2 levels (P < 0.05 in all cases), when letrozole was administered. This suggests that letrozole treatment might improve sperm count in an NOA sub-population; however, more studies, including the proper controls, are needed to confirm its efficacy. Asian Journal of Andrology (2011) 13, 895-897; doi:10.1038/aja.2011.44; published online 27 June 2011

引用

页码：895 / 897

页数：3

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