Effect of Perfluorohexane on the Expression of Cellular Adhesion Molecules and Surfactant Protein A in Human Mesothelial Cells In Vitro

被引：2

作者：

Haufe, Dirk ^{[1
]}

Dahmen, Klaus G. ^{[1
]}

Tiebel, Oliver ^{[2
]}

Huebler, Matthias ^{[1
]}

Koch, Thea ^{[1
]}

机构：

[1] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Anesthesiol & Intens Care Med, D-01307 Dresden, Germany

[2] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Lab Med, D-01307 Dresden, Germany

来源：

ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY | 2011年 / 39卷 / 04期

关键词：

perfluorocarbon; mesothelial cells; cellular adhesion molecules; surfactant protein A; PARTIAL LIQUID VENTILATION; ACUTE RESPIRATORY-DISTRESS; INDUCED LUNG INJURY; ALVEOLAR MACROPHAGES; INFLAMMATORY RESPONSE; ENDOTHELIAL-CELLS; PERITONEAL-LAVAGE; EPITHELIAL-CELLS; GENE-EXPRESSION; TNF-ALPHA;

D O I：

10.3109/10731199.2010.550264

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The intraperitoneal instillation of perfluorocarbons augmented systemic oxygenation and was protective in mesenteric ischemia-reperfusion and experimental lung injury. To study biocompatibility and potential anti-inflammatory effects of intraperitoneal perfluorocarbons, we evaluated the influence of perfluorohexane and/or inflammatory stimuli on human mesothelial cells in vitro. Perfluorohexane exposure neither impaired cell viability nor induced cellular activation. TNF alpha enhanced ICAM-1 expression, which was not attenuated by simultaneous perfluorohexane treatment. Concentration of intracellular surfactant protein A tended to be higher in perfluorohexane treated cells compared to controls. Our in vitro data add further evidence that intraperitoneal perfluorocarbon application is feasible without adverse local effects.

引用

页码：239 / 246

页数：8

共 39 条

[1] Perfluorocarbon blocks tumor necrosis factor-α-induced interleukin-8 release from alveolar epithelial cells in vitro [J].