The Microbiome-Gut-Brain Axis, a Potential Therapeutic Target for Substance-Related Disorders

被引：15
作者：
Fu, Xuan [1 ,2 ,3 ,4 ,5 ,6 ]
Chen, Ti [7 ]
Cai, Jingda [1 ,2 ,3 ,4 ,5 ,6 ]
Liu, Bo [1 ,2 ,3 ,4 ,5 ,6 ]
Zeng, Yaohui [1 ,2 ,3 ,4 ,5 ,6 ]
Zhang, Xiaojie [1 ,2 ,3 ,4 ,5 ,6 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Peoples R China
[2] Natl Clin Res Ctr Mental Disorders, Changsha, Peoples R China
[3] Natl Technol Inst Mental Disorders, Changsha, Peoples R China
[4] Hunan Med Ctr Mental Hlth, Changsha, Peoples R China
[5] Hunan Key Lab Psychiat & Mental Hlth, Changsha, Peoples R China
[6] Cent South Univ, Mental Hlth Inst, Changsha, Peoples R China
[7] Cent South Univ, Xiangya Hosp 3, Dept Lab Med, Changsha, Peoples R China
来源：
FRONTIERS IN MICROBIOLOGY | 2021年 / 12卷
关键词：
microbiome-gut-brain axis (MGBA); microbiota manipulation; substance-related disorders; gut microbiota; fecal microbiome transplantation; INDUCED LIVER-INJURY; INTESTINAL PERMEABILITY; RIFAXIMIN IMPROVES; INDUCED ANXIETY; ALCOHOL; TRANSPLANTATION; DYSREGULATION; ASSOCIATIONS; ADDICTION; DYSBIOSIS;
D O I：
10.3389/fmicb.2021.738401
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Substance addiction is a complex worldwide public health problem. It endangers both personal life and social stability, causing great loss on economy. Substance-related disorder is considered to be a complicated chronic brain disorder. It resulted from interactions among pharmacological properties of addictive substances, individual susceptibility, and social-environmental factors. Unfortunately, there is still no ideal treatment for this disorder. Recent lines of evidence suggest that gut microbiome may play an important role in the pathogenesis of neuropsychiatric disorders, including substance-related disorders. This review summarizes the research on the relationship between gut microbiome and substance-related disorders, including different types of substance, different individual susceptibility, and the occurrence and development of substance-induced mental disorders. We also discuss the potentiation of gut microbiome in the treatment of substance-related disorders, especially in the treatment of substance-induced mental disorders and manipulation on individuals' responsiveness to addictive substances.
引用
收藏
页数：17
相关论文
共 93 条
[1]  
Acharya C, 2017, ALIMENT PHARM THER, V45, P319, DOI [10.1111/apt.13858, 10.1111/apt.14585]
[2]   Gut microbiota compositional and functional fingerprint in patients with alcohol use disorder and alcohol-associated liver disease [J].
Addolorato, Giovanni ;
Ponziani, Francesca R. ;
Dionisi, Tommaso ;
Mosoni, Carolina ;
Vassallo, Gabriele A. ;
Sestito, Luisa ;
Petito, Valentina ;
Picca, Anna ;
Marzetti, Emanuele ;
Tarli, Claudia ;
Mirijello, Antonio ;
Zocco, Maria Assunta ;
Lopetuso, Loris R. ;
Antonelli, Mariangela ;
Rando, Maria M. ;
Paroni Sterbini, Francesco ;
Posteraro, Brunella ;
Sanguinetti, Maurizio ;
Gasbarrini, Antonio .
LIVER INTERNATIONAL, 2020, 40 (04) :878-888
[3]   Differential effects of synthetic psychoactive cathinones and amphetamine stimulants on the gut microbiome in mice [J].
Angoa-Perez, Mariana ;
Zagorac, Branislava ;
Winters, Andrew D. ;
Greenberg, Jonathan M. ;
Ahmad, Madison ;
Theis, Kevin R. ;
Kuhn, Donald M. .
PLOS ONE, 2020, 15 (01)
[4]   A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder [J].
Bajaj, Jasmohan S. ;
Gavis, Edith A. ;
Fagan, Andrew ;
Wade, James B. ;
Thacker, Leroy R. ;
Fuchs, Michael ;
Patel, Samarth ;
Davis, Brian ;
Meador, Jill ;
Puri, Puneet ;
Sikaroodi, Masoumeh ;
Gillevet, Patrick M. .
HEPATOLOGY, 2021, 73 (05) :1688-1700
[5]   Alcohol, liver disease and the gut microbiota [J].
Bajaj, Jasmohan S. .
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2019, 16 (04) :235-246
[6]   Continued Alcohol Misuse in Human Cirrhosis is Associated with an Impaired Gut-Liver Axis [J].
Bajaj, Jasmohan S. ;
Kakiyama, Genta ;
Zhao, Derrick ;
Takei, Hajime ;
Fagan, Andrew ;
Hylemon, Phillip ;
Zhou, Huiping ;
Pandak, William M. ;
Nittono, Hiroshi ;
Fiehn, Oliver ;
Salzman, Nita ;
Holtz, Mary ;
Simpson, Pippa ;
Gavis, Edith A. ;
Heuman, Douglas M. ;
Liu, Runping ;
Kang, Dae Joong ;
Sikaroodi, Masoumeh ;
Gillevet, Patrick M. .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2017, 41 (11) :1857-1865
[7]   Acute Binge Drinking Increases Serum Endotoxin and Bacterial DNA Levels in Healthy Individuals [J].
Bala, Shashi ;
Marcos, Miguel ;
Gattu, Arijeet ;
Catalano, Donna ;
Szabo, Gyongyi .
PLOS ONE, 2014, 9 (05)
[8]   Opioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation [J].
Banerjee, S. ;
Sindberg, G. ;
Wang, F. ;
Meng, J. ;
Sharma, U. ;
Zhang, L. ;
Dauer, P. ;
Chen, C. ;
Dalluge, J. ;
Johnson, T. ;
Roy, S. .
MUCOSAL IMMUNOLOGY, 2016, 9 (06) :1418-1428
[9]   Probiotics and prebiotics: focus on psychiatric disorders - a systematic review [J].
Barbosa, Renata S. D. ;
Vieira-Coelho, Maria A. .
NUTRITION REVIEWS, 2020, 78 (06) :437-450
[10]   Cocaine alters the gut microbiome in a self-administration rat model: Reversal by dehydroepiandrosterone treatment [J].
Bareli, T. ;
Haput, R. ;
Levi-Ahdoot, H. ;
Nissan, H. ;
Koren, O. ;
Yadid, G. .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2019, 29 :S495-S496
12345678910