Household Transmission of Influenza (H1N1-2009) in Japan: Age-specificity and Reduction of Household Transmission Risk by Zanamivir Treatment

被引：37

作者：

Nishiura, H. ^{[1
,2
]}

Oshitani, H. ^{[3
]}

机构：

[1] Univ Utrecht, NL-3584 CL Utrecht, Netherlands

[2] Japan Sci & Technol Agcy, PRESTO, Saitama, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Virol, Sendai, Miyagi 980, Japan

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2011年 / 39卷 / 02期

基金：

日本科学技术振兴机构;

关键词：

INFLUENZA; H1N1-2009; EPIDEMIOLOGY; PANDEMIC; ANTIVIRAL DRUGS; NEURAMINIDASE INHIBITORS; PROPHYLAXIS; OSELTAMIVIR; ZANAMIVIR; A H1N1 VIRUS; PANDEMIC INFLUENZA; INFECTION; OSELTAMIVIR; INTERVAL; DISEASE; TRIALS;

D O I：

10.1177/147323001103900231

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study investigated household transmission data for influenza (H1N1-2009) in Japan in order to quantify the age-specific risk of infection and estimate the impact of antiviral treatment on the risk of household transmission. Among a total of 1547 households, involving 4609 household contacts, the secondary attack ratio (SAR) was estimated to be 11.4%. School children aged 5 - 18 years dominated the index cases. Age-specific infectiousness and susceptibility were highest among 0 - 4-year olds, with SAR estimated at 19.4% and 29.6%, respectively. Zanamivir treatment within 24 and 24 - 48 h of illness onset in index cases, respectively, reduced the risk of household transmission to 0.57 (95% CI 0.44, 0.73) and 0.58 (95% CI 0.38, 0.86) times that among those receiving the same treatment at > 48 h and those not receiving treatment. The preventive performance of antiviral treatment and prophylaxis should be further examined in randomized controlled trials.

引用

页码：619 / 628

页数：10

共 26 条

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