Signaling pathways in breast cancer metastasis - novel insights from functional genomics

被引：36

作者：

Blanco, Mario Andres ^{[1
]}

Kang, Yibin ^{[1
,2
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

[2] Canc Inst New Jersey, Breast Canc Program, New Brunswick, NJ 08903 USA

来源：

BREAST CANCER RESEARCH | 2011年 / 13卷 / 02期

基金：

美国国家卫生研究院;

关键词：

ASTROCYTE ELEVATED GENE-1; EPITHELIAL-CELLS; CLINICAL-IMPLICATIONS; EXPRESSION PATTERNS; DISTANT METASTASES; MULTIPLE CANCERS; HYPOXIA METAGENE; BONE METASTASIS; LUNG METASTASIS; PRIMARY TUMOR;

D O I：

10.1186/bcr2831

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The advent of genomic profiling technology has brought about revolutionary changes in our understanding of breast cancer metastasis. Gene expression analyses of primary tumors have been used to predict metastatic propensity with high accuracy. Animal models of metastasis additionally off er a platform to experimentally dissect components of the metastasis genetic program. Recent integrated studies have synergized clinical bioinformatic analyses with advanced experimental methodology and begun to uncover the identities and dynamics of signaling programs driving breast cancer metastasis. Such functional genomics studies hold great promise for understanding the genetic basis of metastasis and improving therapeutics for advanced diseases.

引用

页数：9

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