Design, Synthesis and Characterization of Novel Isoxazole Tagged Indole Hybrid Compounds

被引：6

作者：

Al-Qawasmeh, Raed A. ^{[1
,2
]}

Al-Nazer, Louy A. ^{[2
]}

Dawlat-Kari, Sarah A. ^{[2
]}

Abu-Qatouseh, Luay ^{[4
]}

Sabri, Salim S. ^{[2
]}

AlDamen, Murad A. ^{[2
]}

Sinnokrot, Mutasem ^{[3
]}

机构：

[1] Univ Sharjah, Coll Sci, Dept Chem, Sharjah 27272, U Arab Emirates

[2] Univ Jordan, Dept Chem, Amman 11942, Jordan

[3] Khalifa Univ Sci & Technol, Coll Arts & Sci, Dept Chem, Abu Dhabi 127788, U Arab Emirates

[4] Univ Petra, Med Microbiol & Immunol, Amman, Jordan

来源：

OPEN CHEMISTRY | 2020年 / 18卷 / 01期

关键词：

isoxazole; indole; click chemistry; 1,3-dipolar cycloaddition; Alkyne; Copper (I); CLICK CHEMISTRY; DERIVATIVES; ANTICANCER; MOLECULE;

D O I：

10.1515/chem-2020-0017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sixteen new isoxazole tagged indole compounds have been synthesized via copper (I) catalyzed click chemistry of the aryl hydroxamoyl chloride and an indole containing alkyne moiety. The chemical structure of the synthesized compounds has been established using various physicochemical techniques. X-ray single crystal analysis of Ethyl 1-((3-phenylisoxazol-5-yl) methyl)-1H-indole-2-carboxylate (8a) has been analyzed. All compounds were tested for their antibacterial and anticancer activities. The activities for the new compounds were weak against both bacterial strains and the cancer cell lines.

引用

页码：138 / 148

页数：11

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