Finding the right target for drug-resistant inflammatory bowel disease

被引：6

作者：

Cader, M. Zaeem

Kaser, Arthur ^{[1
]}

机构：

[1] Univ Cambridge, Cambridge Inst Therapeut Immunol & Infect Dis, Jeffrey Cheah Biomed Ctr, Cambridge, England

来源：

NATURE MEDICINE | 2021年 / 27卷 / 11期

关键词：

MAINTENANCE THERAPY; INDUCTION; VEDOLIZUMAB;

D O I：

10.1038/s41591-021-01551-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A translational study reveals a role for interleukin-1-fibroblast-neutrophil signaling in drug-resistant inflammatory bowel disease, opening a potential path to targeted treatment.

引用

页码：1870 / 1871

页数：2

共 12 条

[1] Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice [J].

Bersudsky, Marina ;

Luski, Lotem ;

Fishman, Daniel ;

White, Rosalyn M. ;

Ziv-Sokolovskaya, Nadya ;

Dotan, Shahar ;

Rider, Peleg ;

Kaplanov, Irena ;

Aychek, Tegest ;

Dinarello, Charles A. ;

Apte, Ron N. ;

Voronov, Elena .

GUT, 2014, 63 (04) :598-609

[2] Cross-tissue organization of the fibroblast lineage [J].

Buechler, Matthew B. ;

Pradhan, Rachana N. ;

Krishnamurty, Akshay T. ;

Cox, Christian ;

Calviello, Aslihan Karabacak ;

Wang, Amber W. ;

Yang, Yeqing Angela ;

Tam, Lucinda ;

Caothien, Roger ;

Roose-Girma, Merone ;

Modrusan, Zora ;

Arron, Joseph R. ;

Bourgon, Richard ;

Muller, Soren ;

Turley, Shannon. J. .

NATURE, 2021, 593 (7860) :575-+

[3] 25 years of anti-TNF treatment for inflammatory bowel disease: lessons from the past and a look to the future [J].

D'Haens, Geert R. ;

van Deventer, Sander .

GUT, 2021, 70 (07) :1396-1405

[4] Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease [J].

Feagan, B. G. ;

Sandborn, W. J. ;

Gasink, C. ;

Jacobstein, D. ;

Lang, Y. ;

Friedman, J. R. ;

Blank, M. A. ;

Johanns, J. ;

Gao, L. -L. ;

Miao, Y. ;

Adedokun, O. J. ;

Sands, B. E. ;

Hanauer, S. B. ;

Vermeire, S. ;

Targan, S. ;

Ghosh, S. ;

de Villiers, W. J. ;

Colombel, J. -F. ;

Tulassay, Z. ;

Seidler, U. ;

Salzberg, B. A. ;

Desreumaux, P. ;

Lee, S. D. ;

Loftus, E. V., Jr. ;

Dieleman, L. A. ;

Katz, S. ;

Rutgeerts, P. .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (20) :1946-1960

[5] Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis [J].

Feagan, Brian G. ;

Rutgeerts, Paul ;

Sands, Bruce E. ;

Hanauer, Stephen ;

Colombel, Jean-Frederic ;

Sandborn, William J. ;

Van Assche, Gert ;

Axler, Jeffrey ;

Kim, Hyo-Jong ;

Danese, Silvio ;

Fox, Irving ;

Milch, Catherine ;

Sankoh, Serap ;

Wyant, Tim ;

Xu, Jing ;

Parikh, Asit .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (08) :699-710

[6]

Friedrich M, NAT MED, DOI [10.1038/s41591-021-01520-5(2021), DOI 10.1038/S41591-021-01520-5(2021)]

[7] Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease [J].

Kinchen, James ;

Chen, Hannah H. ;

Parikh, Kaushal ;

Antanaviciute, Agne ;

Jagielowicz, Marta ;

Fawkner-Corbett, David ;

Ashley, Neil ;

Cubitt, Laura ;

Mellado-Gomez, Esther ;

Attar, Moustafa ;

Sharma, Eshita ;

Wills, Quin ;

Bowden, Rory ;

Richter, Felix C. ;

Ahern, David ;

Puri, Kamal D. ;

Henault, Jill ;

Gervais, Francois ;

Koohy, Hashem ;

Simmons, Alison .

CELL, 2018, 175 (02) :372-+

[8] Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis [J].

Sandborn, William J. ;

Su, Chinyu ;

Sands, Bruce E. ;

D'Haens, Geert R. ;

Vermeire, Severine ;

Schreiber, Stefan ;

Danese, Silvio ;

Feagan, Brian G. ;

Reinisch, Walter ;

Niezychowski, Wojciech ;

Friedman, Gary ;

Lawendy, Nervin ;

Yu, Dahong ;

Woodworth, Deborah ;

Mukherjee, Arnab ;

Zhang, Haiying ;

Healey, Paul ;

Panes, Julian .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (18) :1723-1736

[9] Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease [J].

Sandborn, William J. ;

Feagan, Brian G. ;

Rutgeerts, Paul ;

Hanauer, Stephen ;

Colombel, Jean-Frederic ;

Sands, Bruce E. ;

Lukas, Milan ;

Fedorak, Richard N. ;

Lee, Scott ;

Bressler, Brian ;

Fox, Irving ;

Rosario, Maria ;

Sankoh, Serap ;

Xu, Jing ;

Stephens, Kristin ;

Milch, Catherine ;

Parikh, Asit .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (08) :711-721

[10] Trial summary and protocol for a phase II randomised placebo-controlled double-blinded trial of Interleukin 1 blockade in Acute Severe Colitis: the IASO trial [J].

Thomas, Martin Geoffrey ;

Bayliss, Carrie ;

Bond, Simon ;

Dowling, Francis ;

Galea, James ;

Jairath, Vipul ;

Lamb, Christopher ;

Probert, Christopher ;

Timperley-Preece, Elizabeth ;

Watson, Alastair ;

Whitehead, Lynne ;

Williams, John G. ;

Parkes, Miles ;

Kaser, Arthur ;

Raine, Tim .

BMJ OPEN, 2019, 9 (02)

← 1 2 →