Influence of food intake on the QT and QT/RR relation

被引：6

作者：

Sciot, Bram ^{[1
]}

Vandenberk, Bert ^{[1
,2
]}

Huijghebaert, Suzy

Goovaerts, Griet ^{[3
,4
]}

Van Huffel, Sabine ^{[3
,4
]}

Ector, Joris ^{[1
,2
]}

Willems, Rik ^{[1
,2
]}

机构：

[1] Univ Hosp Leuven, Dept Cardiol, Herestr 49, B-3000 Leuven, Belgium

[2] Univ Leuven, Dept Cardiovasc Sci, Leuven, Belgium

[3] Univ Leuven, Dept Elect Engn ESAT, STADIUS Ctr Dynam Syst Signal Proc & Data Analyt, Leuven, Belgium

[4] IMinds Med IT, Leuven, Belgium

来源：

JOURNAL OF ELECTROCARDIOLOGY | 2016年 / 49卷 / 05期

基金：

欧洲研究理事会;

关键词：

QT interval; QT correction; Heart rate; Meal intake; Thorough QT studies; THOROUGH QT; HEART-RATE; CARDIAC REPOLARIZATION; INTERVAL PROLONGATION; CLINICAL-PHASE; MEAL INTAKE; ACTIVATION; INGESTION; RESPONSES; DESIGN;

D O I：

10.1016/j.jelectrocard.2016.06.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: There are conflicting data on the influence of meal intake on the QT interval. Methods: Ten healthy subjects were studied before and after a standardized breakfast and lunch with a sequence of supine resting, standing and exercise. Data collection was performed using a 12-lead Holter with semi-automated analysis. QT correction was performed using Fridericia (QTcF) correction formula and a subject-specific method based on individual QT/RR-regression (QTcI). Results: Meal intake induced significant changes in HR (p < 0.001), but not in QTcF (p = 0.512) or QTcI (p = 0.739). Postural analysis showed only significant differences in supine position for HR (p = 0.010), not when standing or during exercise. Conclusion: Food intake induced an increase in heart rate limited to supine position. Using QTcF and QTcI no QTc changes were found. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：720 / 727

页数：8

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