Palladium-catalyzed cross-coupling of 2-iodobiphenyls with ortho-chloroacetophenones through dual C-H arylation for the construction of tribenzo[a,c,f]cyclooctanones

被引：1
作者：
Zuo, Xiang [1 ]
Cheng, Cang [1 ]
Zhang, Yanghui [1 ]
机构：
[1] Tongji Univ, Sch Chem Sci & Engn, Shanghai Key Lab Chem Assessment & Sustainabil, 1239 Siping Rd, Shanghai 200092, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 18期
基金：
中国国家自然科学基金;
关键词：
DERIVATIVES; PLANAR; CYCLIZATION; INSERTION; PD; ACTIVATION; FLUORENE;
D O I：
10.1039/d2qo00647b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The palladium-catalyzed cross-coupling reaction of 2-iodobiphenyls with ortho-chloroacetophenones has been developed. The reaction involves C-H activation of 2-iodobiphenyls and yields eight-membered carbocycles by forming two C-C bonds. The protocol provides a straightforward method for the construction of tribenzo[a,c,f]cyclooctanones with simple substrates and allows easy access to its various derivatives.
引用
收藏
页码：4937 / 4942
页数：6
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