Signaling mucins: The new kids on the MAPK block

被引:19
作者
Cullen, Paul J. [1 ]
机构
[1] SUNY Buffalo, Dept Biol Sci, Buffalo, NY 14260 USA
来源
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION | 2007年 / 17卷 / 03期
关键词
signal transduction; glycosylation; RAS; Cdc42; protease; Notch;
D O I
10.1615/CritRevEukarGeneExpr.v17.i3.50
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Signaling mucins are an emerging group of cell adhesion receptors that activate mitogen-activated protein kinase (MAPK) pathways at the level of RAS/RHO. Recent discoveries on several fronts, including in the model eukaryote budding yeast, have broadened our understanding of this family of signaling molecules. Progress in characterizing three signaling mucins, MUC1, Muc4, and Msb2, points to a surprising degree of fiinctional overlap in the regulation and mechanism-of-activation of these molecules. The prevailing new insight is one of receptor activation by proteolytic cleavage that closely mirrors the developmental signaling factor, Notch. The unexpected parallels between signaling mucins and Notch spark new questions about mucin activation and provoke a double take at this fledgling class of signaling adhesion molecule.
引用
收藏
页码:241 / 257
页数:17
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