Convenient and stereospecific synthesis of trans-1,3-disubstituted imidazolidines and their transformation to 2,3-diamino-3-phenylpropanoic acids

被引：6

作者：

Kavrakova, IK ^{[1
]}

Lyapova, MJ ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Ctr Phytochem, Inst Organ Chem, BU-1113 Sofia, Bulgaria

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 2000年 / 65卷 / 10期

关键词：

amino acids; 2,3-diaminocarboxylic acids; imidazolidines; ring cleavage; reductions; steric interactions;

D O I：

10.1135/cccc20001580

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Conversion of the easily available trans-2-oxoimidazolidine-4-carboxylic acid 1 to the corresponding imidazolidines 8 gives after one-step oxidation and ring cleavage the diamino acid 2 in high yield. The difference in the trans-vicinal couplings for the hydrogen-bonded and nonbonded compounds suggests different ring geometry as a result of the balancing effect of the N-1 substituent on the "allylic strain".

引用

页码：1580 / 1586

页数：7

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