Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis

被引:7
作者
Caputi, Luigi [1 ]
Boncoraglio, Giorgio B. [2 ]
Bernardi, Gaetano [3 ]
Ciusani, Emilio [3 ]
Dantes, Marcello [4 ]
de Liso, Federica [5 ]
Erbetta, Alessandra [6 ]
Marucci, Gianluca [7 ]
Matinato, Caterina [5 ]
Corsini, Elena [3 ]
机构
[1] Maggiore Hosp ASST Crema, Dept Cardio Cerebrovasc Dis, Neurol Unit, I-26013 Crema, Italy
[2] Fdn IRCCS Ist Neurol Carlo Besta, Dept Cerebrovasc Dis, I-20133 Milan, Italy
[3] Fdn IRCCS Ist Neurol Carlo Besta, Dept Diagnost & Technol, I-20133 Milan, Italy
[4] IRCCS Humanitas Res Hosp, Dept Reumatol, I-20089 Rozzano, Italy
[5] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Lab Clin Chem & Microbiol, I-20122 Milan, Italy
[6] Fdn IRCCS Ist Neurol Carlo Besta, Dept Technol & Diag, Neuroradiol Unit, I-20133 Milan, Italy
[7] Fdn IRCCS Ist Neurol Carlo Besta, Neuropathol Unit, I-20133 Milan, Italy
关键词
neurological autoimmune disorders; rheumatoid meningitis; anti-cyclic citrullinated peptide antibody; NERVOUS-SYSTEM INVOLVEMENT; PEARLS;
D O I
10.3390/biomedicines10102401
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rheumatoid meningitis (RM) is a rare but often aggressive neurological complication of rheumatoid arthritis. The diagnosis of RM, besides the clinical, radiological, and laboratory criteria, usually requires a cerebral biopsy. Based on the two cases presented in this paper, we propose a new laboratory marker. Cerebrospinal fluid and serum anti-cyclic citrullinated peptide (CCP) IgG were measured, and the intrathecal synthesis of anti-CCP antibodies (anti-CCP antibody index) was calculated using the hyperbolic function. The anti-CCP antibody index was positive in both cases at first diagnosis and progressively decreased after treatments. Together with clinical and radiological criteria, the calculation of the anti-CCP intrathecal synthesis, more than the simple measurement of serum or cerebrospinal fluid anti-CCP antibody titers, may represent a useful tool for RM diagnosis and, possibly, for treatment response.
引用
收藏
页数:9
相关论文
共 36 条
[31]   Diffuse chronic leptomeningitis with seropositive rheumatoid arthritis: report of a case successfully treated as rheumatoid leptomeningitis [J].
Shimada, Kota ;
Matsui, Toshihiro ;
Kawakami, Misato ;
Hayakawa, Hiromi ;
Futami, Hidekazu ;
Michishita, Kazuya ;
Takaoka, Hirokazu ;
Ikenaka, Tatsuoh ;
Komiya, Akiko ;
Nakayama, Hisanori ;
Hagiwara, Futoshi ;
Sugii, Shoji ;
Furukawa, Hiroshi ;
Ozawa, Yoshinori ;
Tohma, Shigeto .
MODERN RHEUMATOLOGY, 2009, 19 (05) :556-562
[32]   Rheumatoid Meningitis a Rare Extra-Articular Manifestation of Rheumatoid Arthritis: Report of 6 Cases and Literature Review [J].
Trabelsi, Melanie ;
Romand, Xavier ;
Gilson, Melanie ;
Vaillant, Mathieu ;
Guerne, Pierre-Andre ;
Hayem, Gilles ;
Bertolini, Ewa ;
Baillet, Athan ;
Gaudin, Philippe .
JOURNAL OF CLINICAL MEDICINE, 2020, 9 (06)
[33]  
Tsuzaki K, 2017, CASE REP NEUROL MED, V2017, DOI 10.1155/2017/7638539
[34]   Rheumatoid meningitis: A systematic review and meta-analysis [J].
Villa, Eduardo ;
Sarquis, Teresita ;
de Grazia, Jose ;
Nunez, Rene ;
Alarcon, Pablo ;
Villegas, Rodrigo ;
Guevara, Carlos .
EUROPEAN JOURNAL OF NEUROLOGY, 2021, 28 (09) :3201-3210
[35]   Systematic Review: Accuracy of Anti-Citrullinated Peptide Antibodies for Diagnosing Rheumatoid Arthritis [J].
Whiting, Penny F. ;
Smidt, Nynke ;
Sterne, Jonathan A. C. ;
Harbord, Roger ;
Burton, Anya ;
Burke, Margaret ;
Beynon, Rebecca ;
Ben-Shlomo, Yoav ;
Axford, John ;
Dieppe, Paul .
ANNALS OF INTERNAL MEDICINE, 2010, 152 (07) :456-W166
[36]   Rheumatoid-associated meningitis and vasculopathy [J].
Yeaney, Gabrielle A. ;
Denby, Elizabeth L. ;
Jahromi, Babak S. ;
Mangla, Rajiv .
NEUROLOGY, 2015, 84 (16) :1717-1718