Anti-Cyclic Citrullinated Peptide Antibody Index in the Cerebrospinal Fluid for the Diagnosis and Monitoring of Rheumatoid Meningitis

被引:7
作者
Caputi, Luigi [1 ]
Boncoraglio, Giorgio B. [2 ]
Bernardi, Gaetano [3 ]
Ciusani, Emilio [3 ]
Dantes, Marcello [4 ]
de Liso, Federica [5 ]
Erbetta, Alessandra [6 ]
Marucci, Gianluca [7 ]
Matinato, Caterina [5 ]
Corsini, Elena [3 ]
机构
[1] Maggiore Hosp ASST Crema, Dept Cardio Cerebrovasc Dis, Neurol Unit, I-26013 Crema, Italy
[2] Fdn IRCCS Ist Neurol Carlo Besta, Dept Cerebrovasc Dis, I-20133 Milan, Italy
[3] Fdn IRCCS Ist Neurol Carlo Besta, Dept Diagnost & Technol, I-20133 Milan, Italy
[4] IRCCS Humanitas Res Hosp, Dept Reumatol, I-20089 Rozzano, Italy
[5] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Lab Clin Chem & Microbiol, I-20122 Milan, Italy
[6] Fdn IRCCS Ist Neurol Carlo Besta, Dept Technol & Diag, Neuroradiol Unit, I-20133 Milan, Italy
[7] Fdn IRCCS Ist Neurol Carlo Besta, Neuropathol Unit, I-20133 Milan, Italy
关键词
neurological autoimmune disorders; rheumatoid meningitis; anti-cyclic citrullinated peptide antibody; NERVOUS-SYSTEM INVOLVEMENT; PEARLS;
D O I
10.3390/biomedicines10102401
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Rheumatoid meningitis (RM) is a rare but often aggressive neurological complication of rheumatoid arthritis. The diagnosis of RM, besides the clinical, radiological, and laboratory criteria, usually requires a cerebral biopsy. Based on the two cases presented in this paper, we propose a new laboratory marker. Cerebrospinal fluid and serum anti-cyclic citrullinated peptide (CCP) IgG were measured, and the intrathecal synthesis of anti-CCP antibodies (anti-CCP antibody index) was calculated using the hyperbolic function. The anti-CCP antibody index was positive in both cases at first diagnosis and progressively decreased after treatments. Together with clinical and radiological criteria, the calculation of the anti-CCP intrathecal synthesis, more than the simple measurement of serum or cerebrospinal fluid anti-CCP antibody titers, may represent a useful tool for RM diagnosis and, possibly, for treatment response.
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页数:9
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