Investigation into the Pathology of Idiopathic Systemic Amyloidosis in Four Captive Badgers (Meles meles)

被引：2

作者：

Bianco, C. ^{[1
]}

Sanchez-Cordon, P. J. ^{[2
]}

Verin, R. ^{[3
]}

Godinho, A. ^{[1
,5
,6
]}

Weyer, U. ^{[4
]}

Lesellier, S. ^{[4
]}

Spiropoulos, J. ^{[2
]}

Floyd, T. ^{[2
]}

Everest, D. ^{[2
]}

Nunez, A. ^{[2
]}

机构：

[1] Anim & Plant Hlth Agcy, Pathol Dept, Lasswade, Scotland

[2] Anim & Plant Hlth Agcy, Pathol Dept, Weybridge, Surrey, England

[3] Univ Padua, Dept Comparat Biomed & Food Sci, Padua, Italy

[4] Anim & Plant Hlth Agcy, Weybridge, Surrey, England

[5] ICVS 3Bs PT Govt Associate Lab, Braga, Portugal

[6] Univ Minho, Sch Med, Life & Hlth Sci Res Inst, Braga, Portugal

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 2020年 / 176卷

关键词：

amyloidosis; badger; histopathology; pathology; AA AMYLOIDOSIS; DIAGNOSIS;

D O I：

10.1016/j.jcpa.2020.02.012

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Systemic idiopathic amyloidosis was described in four captive badgers (Meles meles). Two animals (B1 and B2) were not enrolled in any trial, while animals B3 and B4 took part in a vaccine efficacy study and had been challenged with Mycobacterium bovis. A full set of tissues was collected and processed routinely for histopathological, immunohistochemical and ultrastructural studies. Splenomegaly was found in three out of four animals. Histopathological evaluation revealed congophilic, permanganate-resistant systemic amyloid deposits in the tissues of all badgers. Animals B2 and B4 displayed a marked granulomatous response to amyloid within the spleen. Animals B1 and B2 also displayed clinicopathological findings suggestive of chronic kidney disease. Ultrastructural examination identified peculiar star-shaped arrays of amyloid. Immunohistochemical studies were unrewarding. Systemic amyloidosis should be considered among the differentials of wasting in captive badgers. Crown Copyright (C) 2020 Published by Elsevier Ltd. All rights reserved.

引用

页码：128 / 132

页数：5

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