Drug addiction: bad habits add up

被引:434
作者
Robbins, TW [1 ]
Everitt, BJ [1 ]
机构
[1] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England
基金
英国医学研究理事会;
关键词
D O I
10.1038/19208
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We know how many drugs of abuse - cocaine, heroin and nicotine - work, but less about how they lead to addiction. Studies of the brain-learning systems concerned are addressing the causes of addiction, with the Intent of developing better treatments.
引用
收藏
页码:567 / 570
页数:4
相关论文
共 32 条
[1]   INTRA-CRANICAL SELF-ADMINISTRATION OF MORPHINE INTO THE VENTRAL TEGMENTAL AREA IN RATS [J].
BOZARTH, MA ;
WISE, RA .
LIFE SCIENCES, 1981, 28 (05) :551-555
[2]   Acute effects of cocaine on human brain activity and emotion [J].
Breiter, HC ;
Gollub, RL ;
Weisskoff, RM ;
Kennedy, DN ;
Makris, N ;
Berke, JD ;
Goodman, JM ;
Kantor, HL ;
Gastfriend, DR ;
Riorden, JP ;
Mathew, RT ;
Rosen, BR ;
Hyman, SE .
NEURON, 1997, 19 (03) :591-611
[3]   Activation of memory circuits during cue-elicited cocaine craving [J].
Grant, S ;
London, ED ;
Newlin, DB ;
Villemagne, VL ;
Liu, X ;
Contoreggi, C ;
Phillips, RL ;
Kimes, AS ;
Margolin, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) :12040-12045
[4]   INVOLVEMENT OF D2 DOPAMINE-RECEPTORS IN THE NUCLEUS-ACCUMBENS IN THE OPIATE WITHDRAWAL SYNDROME [J].
HARRIS, GC ;
ASTONJONES, G .
NATURE, 1994, 371 (6493) :155-157
[5]  
HERMAN BH, 1995, NEUROPSYCHOPHARMACOL, V13, P269, DOI 10.1016/0893-133X(95)00140-9
[6]   SELF-INJECTION OF AMPHETAMINE DIRECTLY INTO THE BRAIN [J].
HOEBEL, BG ;
MONACO, AP ;
HERNANDEZ, L ;
AULISI, EF ;
STANLEY, BG ;
LENARD, L .
PSYCHOPHARMACOLOGY, 1983, 81 (02) :158-163
[7]   Drug abuse: Hedonic homeostatic dysregulation [J].
Koob, GF ;
LeMoal, M .
SCIENCE, 1997, 278 (5335) :52-58
[8]   Absence of opiate rewarding effects in mice lacking dopamine D2 receptors [J].
Maldonado, R ;
Saiardi, A ;
Valverde, O ;
Samad, TA ;
Roques, BP ;
Borrelli, E .
NATURE, 1997, 388 (6642) :586-589
[9]   Neurobiological similarities in depression and drug dependence: A self-medication hypothesis [J].
Markou, A ;
Kosten, TR ;
Koob, GF .
NEUROPSYCHOPHARMACOLOGY, 1998, 18 (03) :135-174
[10]   Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings [J].
McCann, UD ;
Szabo, Z ;
Scheffel, U ;
Dannals, RF ;
Ricaurte, GA .
LANCET, 1998, 352 (9138) :1433-1437