Cord Blood Transplantation for Multiple Myeloma: A Study from the Multiple Myeloma Working Group of the Japan Society for Hematopoietic Cell Transplantation

被引：12

作者：

Kawamura, Koji ^{[1
]}

Takamatsu, Hiroyuki ^{[2
]}

Ikeda, Takashi ^{[3
]}

Komatsu, Tsunehiko ^{[4
]}

Aotsuka, Nobuyuki ^{[5
]}

Amano, Itsuto ^{[6
]}

Yamamoto, Go ^{[7
]}

Watanabe, Kentaro ^{[8
]}

Ohno, Yuju ^{[9
]}

Matsue, Kosei ^{[10
]}

Kouzai, Yasuji ^{[11
]}

Tsukada, Nobuhiro ^{[12
]}

Ishiyama, Ken ^{[13
]}

Anzai, Naoyuki ^{[14
]}

Kato, Koji ^{[15
]}

Suzuki, Ritsuro ^{[16
]}

Sunami, Kazutaka ^{[17
]}

Kanda, Yoshinobu ^{[1
]}

机构：

[1] Jichi Med Univ, Saitama Med Ctr, Div Hematol, Saitama 3308503, Japan

[2] Kanazawa Univ, Cellular Transplantat Biol, Kanazawa, Ishikawa, Japan

[3] Shizuoka Canc Ctr, Div Hematol & Stem Cell Transplantat, Shizuoka, Japan

[4] Tsukuba Mem Hosp, Dept Hematol, Tsukuba, Ibaraki, Japan

[5] Japanese Red Cross Soc Narita Hosp, Div Hematol Oncol, Narita, Japan

[6] Nara Med Univ Hosp, Dept Hematol & Resp, Kashihara, Nara, Japan

[7] Federat Natl Publ Serv Personnel Mutual Aid Assoc, Dept Hematol, Tokyo, Japan

[8] Saiseikai Cent Hosp, Dept Hematol Oncol Infect Dis, Tokyo, Japan

[9] Kitakyushu Municipal Med Ctr, Dept Internal Med, Kitakyushu, Fukuoka, Japan

[10] Kameda Med Ctr, Dept Med, Div Hematol Oncol, Kamogawa, Japan

[11] Tokyo Metropolitan Tama Med Ctr, Dept Transfus Med, Tokyo, Japan

[12] Japanese Red Cross Med Ctr, Div Hematol, Tokyo, Japan

[13] Kanazawa Univ Hosp, Dept Hematol, Kanazawa, Ishikawa, Japan

[14] Takatsuki Red Cross Hosp, Dept Hematol & Oncol, Takatsuki, Osaka, Japan

[15] Japanese Red Cross Nagoya First Hosp, Childrens Med Ctr, Dept Hematol & Oncol, Nagoya, Aichi, Japan

[16] Nagoya Univ, Sch Med, Dept Hematopoiet Stem Cell Transplantat Data Mana, Nagoya, Aichi 466, Japan

[17] Natl Hosp Org Okayama Med Ctr, Dept Hematol, Okayama, Japan

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2015年 / 21卷 / 07期

关键词：

Multiple myeloma; Cord blood transplantation; Chronic graft-versus-host disease; Tandem transplantation; TERM-FOLLOW-UP; AUTOLOGOUS TRANSPLANTATION; LENALIDOMIDE MAINTENANCE; ALLOGENEIC TRANSPLANTATION; DONOR; RISK; AUTOGRAFT; LEUKEMIA;

D O I：

10.1016/j.bbmt.2015.02.015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cord blood has been investigated as an alternative source for hematopoietic stem cell transplantation, but information about its use for multiple myeloma is limited. The purpose of this study was to evaluate the feasibility of cord blood transplantation (CBT) for patients with multiple myeloma. Eighty-six patients with multiple myeloma who underwent a first CBT between 2001 and 2011 were included in this retrospective study. Sixty-two of them had received other types of stem cell transplantation before CBT. The cumulative incidences of neutrophil engraftment at day 50, grade II to IV acute graft-versus-host disease (GVHD), and chronic GVHD were 81.4%, 39.0%, and 19.5%, respectively. The incidence of nonrelapse mortality at 2 years was 39.0%, but it was only 6.2% in patients who underwent planned tandem autologous/reduced-intensity conditioning CBT (auto/RIC-CBT). Progression-free survival (PFS) and overall survival (OS) at 6 years were 13.0% and 15.2%, respectively. Less than a partial response before CBT and lack of prior transplantation were independent significant adverse factors for PFS, whereas the presence of prior transplantation and planned tandem transplantation were associated with better OS. OS at 6 years in patients who underwent auto/RIC-CBT was 45.9%. In addition, the development of chronic GVHD was associated with superior PFS. In conclusion, we demonstrated that cord blood is feasible as an alternative graft source for myeloma patients. Although CBT provided long-term survival for a fraction of patients, optimal use of this graft requires further clinical studies. (C) 2015 American Society for Blood and Marrow Transplantation.

引用

页码：1291 / 1298

页数：8

共 40 条

[1] Lenalidomide Maintenance for High-Risk Multiple Myeloma after Allogeneic Hematopoietic Cell Transplantation [J].

Alsina, Melissa ;

Becker, Pamela S. ;

Zhong, Xiaobo ;

Adams, Alexia ;

Hari, Parameswaran ;

Rowley, Scott ;

Stadtmauer, Edward A. ;

Vesole, David H. ;

Logan, Brent ;

Weisdorf, Daniel ;

Qazilbash, Muzaffar ;

Popplewell, Leslie L. ;

McClune, Brian ;

Bensinger, William ;

Riches, Marcie ;

Giralt, Sergio A. ;

Pasquini, Marcelo C. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2014, 20 (08) :1183-1189

[2] Autografting followed by a reduced-intensity conditioning unrelated donor cord blood transplantation for a patient with refractory multiple myeloma: successful engraftment with minimal toxicity [J].

Ando, T ;

Yujiri, T ;

Tominaga, T ;

Shinya, S ;

Takahashi, T ;

Nomiyama, J ;

Seguchi, M ;

Matsubara, A ;

Fujii, Y ;

Tanizawa, Y .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2005, 74 (02) :175-179

[3] Tandem autologous vs autologous plus reduced intensity allogeneic transplantation in the upfront management of multiple myeloma: meta-analysis of trials with biological assignment [J].

Armeson, K. E. ;

Hill, E. G. ;

Costa, L. J. .

BONE MARROW TRANSPLANTATION, 2013, 48 (04) :562-567

[4] Unification of hematopoietic stem cell transplantation registries in Japan and establishment of the TRUMP system [J].

Atsuta, Yoshiko ;

Suzuki, Ritsuro ;

Yoshimi, Ayami ;

Gondo, Hisashi ;

Tanaka, Junji ;

Hiraoka, Akira ;

Kato, Koji ;

Tabuchi, Ken ;

Tsuchida, Masahiro ;

Morishima, Yasuo ;

Mitamura, Makoto ;

Kawa, Keisei ;

Kato, Shunichi ;

Nagamura, Tokiko ;

Takanashi, Minoko ;

Kodera, Yoshihisa .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2007, 86 (03) :269-274

[5] Comparison of Unrelated Cord Blood Transplantation and HLA-Mismatched Unrelated Bone Marrow Transplantation for Adults with Leukemia [J].

Atsuta, Yoshiko ;

Morishima, Yasuo ;

Suzuki, Ritsuro ;

Nagamura-Inoue, Tokiko ;

Taniguchi, Shuichi ;

Takahashi, Satoshi ;

Kai, Shunro ;

Sakamaki, Hisashi ;

Kouzai, Yasushi ;

Kobayashi, Naoki ;

Fukuda, Takahiro ;

Azuma, Hiroshi ;

Takanashi, Minoko ;

Mori, Takehiko ;

Tsuchida, Masahiro ;

Kawase, Takakazu ;

Kawa, Keisei ;

Kodera, Yoshihisa ;

Kato, Shunichi .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2012, 18 (05) :780-787

[6] Disease-specific analyses of unrelated cord blood transplantation compared with unrelated bone marrow transplantation in adult patients with acute leukemia [J].

Atsuta, Yoshiko ;

Suzuki, Ritsuro ;

Nagamura-Inoue, Tokiko ;

Taniguchi, Shuichi ;

Takahashi, Satoshi ;

Kai, Shunro ;

Sakamaki, Hisashi ;

Kouzai, Yasushi ;

Kasai, Masaharu ;

Fukuda, Takahiro ;

Azuma, Hiroshi ;

Takanashi, Minoko ;

Okamoto, Shinichiro ;

Tsuchida, Masahiro ;

Kawa, Keisei ;

Morishima, Yasuo ;

Kodera, Yoshihisa ;

Kato, Shunichi .

BLOOD, 2009, 113 (08) :1631-1638

[7] Lenalidomide Maintenance after Stem-Cell Transplantation for Multiple Myeloma [J].

Attal, Michel ;

Lauwers-Cances, Valerie ;

Marit, Gerald ;

Caillot, Denis ;

Moreau, Philippe ;

Facon, Thierry ;

Stoppa, Anne Marie ;

Hulin, Cyrille ;

Benboubker, Lofti ;

Garderet, Laurent ;

Decaux, Olivier ;

Leyvraz, Serge ;

Vekemans, Marie-Christiane ;

Voillat, Laurent ;

Michallet, Mauricette ;

Pegourie, Brigitte ;

Dumontet, Charles ;

Roussel, Murielle ;

Leleu, Xavier ;

Mathiot, Claire ;

Payen, Catherine ;

Avet-Loiseau, Herve ;

Harousseau, Jean-Luc .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (19) :1782-1791

[8] Reduced intensity-conditioned allogeneic stem cell transplantation for multiple myeloma relapsing or progressing after autologous transplantation: a study by the European Group for Blood and Marrow Transplantation [J].

Auner, H. W. ;

Szydlo, R. ;

van Biezen, A. ;

Iacobelli, S. ;

Gahrton, G. ;

Milpied, N. ;

Volin, L. ;

Janssen, J. ;

Quoc, S. Nguyen ;

Michallet, M. ;

Schoemans, H. ;

el Cheikh, J. ;

Petersen, E. ;

Guilhot, F. ;

Schoenland, S. ;

Ahlberg, L. ;

Morris, C. ;

Garderet, L. ;

de Witte, T. ;

Kroeger, N. .

BONE MARROW TRANSPLANTATION, 2013, 48 (11) :1395-1400

[9] Outcomes for reduced-intensity allogeneic transplantation for multiple myeloma:: an analysis of prognostic factors from the Chronic Leukaemia Working Party of the EBMT [J].

Crawley, C ;

Lalancette, M ;

Szydlo, R ;

Gilleece, M ;

Peggs, K ;

Mackinnon, S ;

Juliusson, G ;

Ahlberg, L ;

Nagler, A ;

Shimoni, A ;

Sureda, A ;

Boiron, JM ;

Einsele, H ;

Chopra, R ;

Carella, A ;

Cavenagh, J ;

Gratwohl, A ;

Garban, F ;

Zander, A ;

Björkstrand, B ;

Niederwieser, D ;

Gahrton, G ;

Apperley, JF .

BLOOD, 2005, 105 (11) :4532-4539

[10] International uniform response criteria for multiple myeloma [J].

Durie, B. G. M. ;

Harousseau, J-L ;

Miguel, J. S. ;

Blade, J. ;

Barlogie, B. ;

Anderson, K. ;

Gertz, M. ;

Dimopoulos, M. ;

Westin, J. ;

Sonneveld, P. ;

Ludwig, H. ;

Gahrton, G. ;

Beksac, M. ;

Crowley, J. ;

Belch, A. ;

Boccadaro, M. ;

Turesson, I. ;

Joshua, D. ;

Vesole, D. ;

Kyle, R. ;

Alexanian, R. ;

Tricot, G. ;

Attal, M. ;

Merlini, G. ;

Powles, R. ;

Richardson, P. ;

Shimizu, K. ;

Tosi, P. ;

Morgan, G. ;

Rajkumar, S. V. .

LEUKEMIA, 2006, 20 (09) :1467-1473

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