Rapid screening of COVID-19 patients using white blood cell scattergrams, a study on 381 patients

被引：19

作者：

Osman, Jennifer ^{[1
]}

Lambert, Jerome ^{[2
,3
,4
]}

Templ, Marie ^{[1
]}

Devaux, Floriane ^{[1
]}

Favre, Remy ^{[1
]}

Flaujac, Claire ^{[1
]}

Bridoux, Delphine ^{[1
]}

Marque-Juillet, Stephanie ^{[5
]}

Bruneel, Fabrice ^{[6
]}

Mignon, Francois ^{[7
]}

Diaz-Flores, Ernesto ^{[8
]}

Hentgen, Veronique ^{[9
]}

Greder-Belan, Alix ^{[10
]}

Azarian, Reza ^{[11
]}

Koukabi, Mehrsa ^{[12
]}

Rousselot, Philippe ^{[13
,14
]}

Raggueneau, Victoria ^{[1
]}

Maneglier, Benjamin ^{[15
]}

机构：

[1] CH Versailles, Dept Hematobiol, 177 Rue Versailles, F-78150 Le Chesnay, France

[2] Univ Freiburg, Inst Med Biometry & Stat, Fac Med, Freiburg, Germany

[3] Univ Freiburg, Med Ctr, Freiburg, Germany

[4] INSERM UMR1153, ECSTRRA Team, Paris, France

[5] CH Versailles, Dept Virol, Le Chesnay, France

[6] CH Versailles, Dept Crit Care, Le Chesnay, France

[7] CH Versailles, Dept Radiol, Le Chesnay, France

[8] UCSF, Dept Pediat, Benioff Childrens Hosp, Helen Diller Comprehens Canc Ctr, San Francisco, CA USA

[9] CH Versailles, Dept Pediat, Le Chesnay, France

[10] CH Versailles, Dept Internal Med & Infect Dis, Le Chesnay, France

[11] CH Versailles, Dept Pneumol, Le Chesnay, France

[12] CH Versailles, Emergency Dept, Le Chesnay, France

[13] CH Versailles, Dept Hematol & Oncol, Le Chesnay, France

[14] Univ Versailles St Quentin En Yvelines & Paris Sa, UMR1184, Versailles, France

[15] CH Versailles, Dept Pharmacol, Le Chesnay, France

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2020年 / 190卷 / 05期

关键词：

COVID-19; SARS-Cov-2; coronavirus; plasmacytoid lymphocytes; white blood cells scattergram; HEMATOLOGY ANALYZER; PNEUMONIA; WUHAN;

D O I：

10.1111/bjh.16943

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Complementary tools are warranted to increase the sensitivity of the initial testing for COVID-19. We identified a specific 'sandglass' aspect on the white blood cell scattergram of COVID-19 patients reflecting the presence of circulating plasmacytoid lymphocytes. Patients were dichotomized as COVID-19-positive or -negative based on reverse transcriptase polymerase chain reaction (RT-PCR) and chest computed tomography (CT) scan results. Sensitivity and specificity of the 'sandglass' aspect were 85 center dot 9% and 83 center dot 5% respectively. The positive predictive value was 94 center dot 3%. Our findings provide a non-invasive and simple tool to quickly categorize symptomatic patients as either COVID-19-probable or -improbable especially when RT-PCR and/or chest CT are not rapidly available.

引用

页码：718 / 722

页数：5

共 14 条

[1] Ai T, 2020, RADIOLOGY, DOI [10.5772/intechopen.80730, DOI 10.1148/radiol.2020200642, 10.26434/chemrxiv.11860137.v1, DOI 10.1148/RADIOL.2020200642, 10.1148/radiol.2020200642]
[2] Performance of Radiologists in Differentiating COVID-19 from Non-COVID-19 Viral Pneumonia at Chest CT
Bai, Harrison X.
Hsieh, Ben
Xiong, Zeng
Halsey, Kasey
Choi, Ji Whae
Tran, Thi My Linh
Pan, Ian
Shi, Lin-Bo
Wang, Dong-Cui
Mei, Ji
Jiang, Xiao-Long
Zeng, Qiu-Hua
Egglin, Thomas K.
Hu, Ping-Feng
Agarwal, Saurabh
Xie, Fang-Fang
Li, Sha
Healey, Terrance
Atalay, Michael K.
Liao, Wei-Hua
[J]. RADIOLOGY, 2020, 296 (02) : E46 - E54
[3] Reactive lymphocytes in patients with Covid-19
Chong, Vanessa C. L.
Lim, Kian Guan Eric
Fan, Bingwen Eugene
Chan, Stephrene S. W.
Ong, Kiat H.
Kuperan, Ponnudurai
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 2020, 189 (05) : 844 - 844
[4] Plasmacytoid lymphocytes in SARS-CoV-2 infection (Covid-19)
Foldes, David
Hinton, Richard
Arami, Siamak
Bain, Barbara J.
[J]. AMERICAN JOURNAL OF HEMATOLOGY, 2020, 95 (07) : 861 - 862
[5] Giacomelli A, Clin Infect Dis
[6] Huang CL, 2020, LANCET, V395, P497, DOI [10.1016/S0140-6736(20)30211-7, 10.1016/S0140-6736(20)30183-5]
[7] Diagnostic Performance of CT and Reverse Transcriptase Polymerase Chain Reaction for Coronavirus Disease 2019: A Meta-Analysis
Kim, Hyungjin
Hong, Hyunsook
Yoon, Soon Ho
[J]. RADIOLOGY, 2020, 296 (03) : E145 - E155
[8] Identification and quantification of high fluorescence-stained lymphocytes as antibody synthesizing/secreting cells using the automated routine Hematology Analyzer XE-2100
Linssen, J.
Jennissen, V.
Hildmann, J.
Reisinger, E.
Schindler, J.
Malchau, G.
Nierhaus, A.
Wielckens, K.
[J]. CYTOMETRY PART B-CLINICAL CYTOMETRY, 2007, 72B (03) : 157 - 166
[9] The inconsistency of "optimal" cutpoints obtained using two criteria based on the receiver operating characteristic curve
Perkins, NJ
Schisterman, EF
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2006, 163 (07) : 670 - 675
[10] Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study
Shi, Heshui
Han, Xiaoyu
Jiang, Nanchuan
Cao, Yukun
Alwalid, Osamah
Gu, Jin
Fan, Yanqing
Zheng, Chuansheng
[J]. LANCET INFECTIOUS DISEASES, 2020, 20 (04) : 425 - 434

← 1 2 →