SARS-CoV-2 mimics a host protein to bypass defences

被引：4
|
作者：
Thomann, Lisa [1 ,2 ,3 ]
Thiel, Volker [1 ,2 ,3 ,4 ]
机构：
[1] Inst Immunol & Virol, CH-3012 Bern, Switzerland
[2] Inst Immunol & Virol, CH-3012 Mittelhausern, Switzerland
[3] Univ Bern, Dept Infect Dis & Pathobiol, Vetsuisse Fac, Bern, Switzerland
[4] Univ Bern, Multidisciplinary Ctr Infect Dis, Bern, Switzerland
来源：
NATURE | 2022年 / 610卷 / 7931期
关键词：
Epigenetics; SARS-CoV-2;
D O I：
10.1038/d41586-022-02930-2
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
It emerges that the SARS-CoV-2 virus has evolved to mimic one of the histone proteins that package DNA in the cell nucleus. This mimicry leads to disrupted gene transcription and a diminished antiviral response.
引用
收藏
页码：262 / 263
页数：2
相关论文
共 50 条
  • [1] SARS-CoV-2 mimics a host protein to bypass defences
    Lisa Thomann
    Volker Thiel
    Nature, 2022, 610 : 262 - 263
  • [2] SARS-CoV-2 plugs defences
    Devi, Sharmila
    LANCET INFECTIOUS DISEASES, 2020, 20 (12): : 1377 - 1377
  • [3] Evolution of the SARS-CoV-2 spike protein in the human host
    Wrobel, Antoni G.
    Benton, Donald J.
    Roustan, Chloe
    Borg, Annabel
    Hussain, Saira
    Martin, Stephen R.
    Rosenthal, Peter B.
    Skehel, John J.
    Gamblin, Steven J.
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [4] Evolution of the SARS-CoV-2 spike protein in the human host
    Antoni G. Wrobel
    Donald J. Benton
    Chloë Roustan
    Annabel Borg
    Saira Hussain
    Stephen R. Martin
    Peter B. Rosenthal
    John J. Skehel
    Steven J. Gamblin
    Nature Communications, 13
  • [5] Protein mimics of fusion core from SARS-CoV-1 can inhibit SARS-CoV-2 entry
    Zhan, Yancheng
    Li, Moxuan
    Gong, Rui
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 736
  • [6] SARS-CoV-2 rewires host chromatin
    Du Toit, Andrea
    NATURE REVIEWS MICROBIOLOGY, 2023, 21 (06) : 343 - 343
  • [7] Host Manipulation Mechanisms of SARS-CoV-2
    Massey, Steven E.
    ACTA BIOTHEORETICA, 2022, 70 (01)
  • [8] Mapping host restriction of SARS-CoV-2
    Gea-Mallorquí E.
    Nature Reviews Immunology, 2021, 21 (1) : 3 - 3
  • [9] SARS-CoV-2 vaccination in the immunocompromised host
    Connolly, Caoilfhionn M.
    Paik, Julie J.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2022, 150 (01) : 56 - 58
  • [10] Host genomics of SARS-CoV-2 infection
    Redin, Claire
    Thorball, Christian W.
    Fellay, Jacques
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2022, 30 (08) : 908 - 914
12345